Purpose Osteoporosis and osteopenia are extremely common and can lead to fragility fractures. The purpose of this study was to determine whether a computer learning system could classify whether a hand radiograph demonstrated osteoporosis based on the second metacarpal cortical percentage. Methods We used the second metacarpal cortical percentage as the osteoporosis predictor. A total of 4,000 posteroanterior (PA) radiographs of the hand were standardized through laterality correction, vertical alignment correction, segmentation, proxy osteoporosis predictor, and full pipeline. Laterality was classified using a LeNet convolutional neural network (CNN). Vertical alignment classification used 2,000 PA x-rays to determine vertical alignment of the second metacarpal. We employed segmentation to determine which pixels belong to the second metacarpal from 1,000 PA x-rays using the FSN-8 CNN. The full pipeline was tested on 265 previously unseen PA x-rays. Results Laterality classification accuracy was 99.62%, with a specificity of 100% and sensitivity of 99.3%. Rotation of the hand within 10 of vertical was accurate in 93.2% of films. Segmentation was 94.8% accurate. Proxy osteoporosis predictor was 88.4% accurate. Full pipeline accuracy was 93.9%. In the testing data set, the CNN had a sensitivity of 82.4% and specificity of 95.7%. In the balanced data set, 6 of 39 osteoporotic films were classified as nonosteoporotic; sensitivity was 82.4% and specificity, 94.3%. Conclusions We have created a series of CNN that can accurately identify osteoporosis from non-osteoporosis. Furthermore, our CNN is able to make adjustments to images based on laterality and vertical alignment. Clinical relevance Convolutional neural network and computer learning can be used as an adjunct to dual-energy x-ray absorptiometry scans or to screen and make appropriate referrals for further workup in patients with suspected osteoporosis.
Abstract-According to NSDUH (National Survey on DrugUse and Health), 20 million Americans consumed drugs in the past few 30 days. Combating illicit drug use is of great interest to public health and law enforcement agencies. Despite of the importance, most of the existing studies on drug uses rely on surveys. Surveys on sensitive topics such as drug use may not be answered truthfully by the people taking them. Selecting a representative sample to survey is another major challenge. In this paper, we explore the possibility of using big multimedia data, including both images and text, from social media in order to discover drug use patterns at fine granularity with respect to demographics. Instagram posts are searched and collected by drug related terms by analyzing the hashtags supplied with each post. A large and dynamic dictionary of frequent drug related slangs is used to find these posts. User demographics are extracted using robust face image analysis algorithms. These posts are then mined to find common trends with regard to the time and location they are posted, and further in terms of age and gender of the drug users. Furthermore, by studying the accounts followed by the users of drug related posts, we extract common interests shared by drug users.
Black-box models in machine learning have demonstrated excellent predictive performance in complex problems and high-dimensional settings. However, their lack of transparency and interpretability restrict the applicability of such models in critical decision-making processes. In order to combat this shortcoming, we propose a novel approach to trading off interpretability and performance in prediction models using ideas from semiparametric statistics, allowing us to combine the interpretability of parametric regression models with performance of nonparametric methods. We achieve this by utilizing a two-piece model: the first piece is interpretable and parametric, to which a second, uninterpretable residual piece is added. The performance of the overall model is optimized using methods from the sufficient dimension reduction literature. Influence function based estimators are derived and shown to be doubly robust. This allows for use of approaches such as Double Machine Learning in estimating our model parameters. We illustrate the utility of our approach via simulation studies and a data application based on predicting the length of stay in the intensive care unit among surgery patients.Preprint. Under review.
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