The Quilombola communities are mostly isolated and deprived of sources of treated water, garbage collection and sewage, consuming fresh water from wells, streams, lakes, among others. This lack of basic infrastructure can be a relevant factor in exposing residents to substances and factors that are harmful to the integrity of their genetic material that can lead to carcinogenesis. Based on this, the objective of this study was to evaluate the genomic and mutagenic/cytotoxic damage in the adult population of two Quilombola communities (one urban and another rural region), in the state of Goiás, Brazil. For this purpose, the leukocyte of peripheral blood Comet Assay in 68 individuals and Micronucleus Test from exfoliated buccal cells of oral mucosa in 21 volunteers were performed. The results evidenced genomic damage, especially for the community of Aparecida de Goiânia city, which detected significant values ( p < 0.05), for the length of the comet’s tail and for of the Olive Tail Moment. In the micronucleus test, significant differences were only detected ( p < 0.05), when it came to the distribution of nuclear changes among the groups. Therefore, it is essential to perform constant population biomonitoring studies to help guarantee health and, consequently, the quality of life.
Laboratory analysis has an impact on the different stages of health: prevention, diagnosis, prognosis and therapeutic. Blood samples were collected from quilombolas representatives of the two communities. The samples were stored with anticoagulants (EDTA and fluoride) and without anticoagulant. Were performers the laboratory tests (blood count, lipidogram, urea, creatinine, glycemia and vitamin D). The results showed that 22% of the quilombolas presented values of glycemia among 100 and 126 mg \ dL. Results of the lipidogram test showed 24.4% presented triglyceride variation above 150 mg / dL; 57.7% presented cholesterol above 190 mg / dL; 35.5% had HDL levels below 40 mg / dL and 66.6% had LDL levels above 110 mg / dL. Regarding the hemogram, 15.5% of the hematocrit tests and 24.4% of the hemoglobin tests were found, with values lower than the reference values. Vitamin D presented 40% of patients with values below 30 ng / mL. Glomerular filtration rate calculations showed that 66.66% presented among mild to severe changes in renal filtration rate. The data obtained, show that was possible to highlight that among the quilombolas, there are metabolic disorders of carbohydrates, lipids and vitamin D, which correlate with changes in BMI, justifying cases of overweight.
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