A novel
nonreleasing antibacterial hydrogel dressing with good reusability
was prepared by polyethylene glycol dimethacrylate, N,N-methylene-bis-acrylamide, methyl methacrylate,
1-vinyl-3-butylimidazolium, and acrylamide. The ionic liquid of 1-vinyl-3-butylimidazolium
was polymerized in the hydrogel to endow the hydrogel dressing with
an antibacterial property. The successful synthesis of the hydrogel
dressing was proven by FT-IR spectroscopy and energy-dispersive spectrometry.
The morphology of the hydrogel was confirmed to be a porous and interconnected
network structure by scanning electron microscopy. The resultant hydrogel
dressing showed many desirable features, such as a good protein adsorption
property and repeatable adhesiveness as well as excellent mechanical
properties. Remarkably, the hydrogel dressing displayed broad antibacterial
activity against bacteria Staphylococcus aureus and Escherichia coli and fungal Candida albicans. In addition, the hydrogel dressing
applied locally on wounded skin of rats could effectively avoid early
infection and further accelerate wound healing. The results indicated
that the nonreleasing antibacterial hydrogel had potential application
in wound dressing.
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