This study aims to study the process of fabricating and characterization nanofibers based on cellulose acetate polymer filled with ceftriaxone and ibuprofen using the electrospinning method as a model for a targeted drug delivery system. Cellulose acetate has been successfully fabricated into nanofibers using the electrospinning method and filled with ceftriaxone and ibuprofen. The resulting nanofibers have an average diameter in the range of 412.5 – 558.5 nm under the conditions of the electrospinning process, namely 22 kV voltage, 15 cm distance, and flow rate. 0.005 mL/min using acetone/DMAc (2:1). Based on the data generated from the FTIR test, homogeneity, and drug release test, it is known that the resulting nanofibers, namely cellulose acetate, cellulose acetate-ceftriaxone, and cellulose acetate-ibuprofen, have good morphological characteristics, homogeneity, and release rate so that they have the potential to be used as a targeted drug delivery system
This study was conducted to characterize cellulose acetate-curcumin composite nanofibers synthesized using the electrospinning method, as a biomaterial mask with antibacterial and antiviral properties. Cellulose acetate-curcumin composite nanofibers were successfully synthesized at a flow rate of 1 mL/hour, a needle-collector distance of 17 cm, and a voltage of 22 kV. The resulted nanofibers have an average diameter in the range of 378.89 nm - 461.76 nm. Based on the results of the FTIR spectrum, no significant shift was found. The results of the contact angle test showed that the average contact angle value increased with the addition of curcumin concentration. The mechanical test results showed that variations in the concentration of curcumin were able to increase the tensile strength and strain values.
Pemberian antibiotik pada pasien yang mengalami infeksi piogenik pada kulit di puskesmas proppo belum berdasarkan pada pola kuman dan sensitifitas antibiotik. Penelitian ini bertujuan untuk mengidentifikasi, isolasi serta uji sensitifitas bakteri terhadap beberapa antibiotik sehingga dapat diketahui jenis antibiotik yang paling paten untuk bakteri Staphylococcus aureus. Hasil pengamatan pada isolat pus menunjukkan adanya Staphylococcus aureus dengan ciri kesesuaian. Agar diperoleh bakteri murni dengan jumlah maksimum maka dilakukan isolasi. Telah berhasil diisolasi dan diidentifikasi ke-4 isolat pus yang tumbuh dan memfermentasi pada plat mannitol salt agar, sel berbentuk bulat bergerombol dan bersifat gram positif baik melalui pewarnaan maupun uji secara biokimia. Hasil uji terhadap Chloramphenicol memiliki nilai rata-rata daya hambat 24.0 mm dengan persentase penggunaan mencapai 75.0 %, sedangkan untuk Cefotaxime sodium memiliki nilai rata-rata zona hambat 10.9 mm dengan persentase penggunaan mencapai 25.0 %. Dapat disimpulkan bahwa ke-4 isolat tersebut kesemuanya diidentifikasi sebagai Staphylococcus aureus dengan zona hambat masing-masing isolat sebesar 23.5 mm, 24.2 mm, 24.0 mm dan 24.3 mm yang menunjukkan sensitif terhadap Chloramphenicol sedangkan zona hambat terhadap Cefotaxime sodium masing-masing isolat adalah 5 mm, 10.5 mm, 14.5 mm dan 13,5 mm yang menunjukkan resisten terhadap penggunaan antibiotik tersebut.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.