Angiogenesis, the growth of new blood capillaries from preexisting vessels, is a crucial process in the development and spread of cancers. The inhibition of angiogenesis thus appears as a promising therapy for cancer. Methionine aminopeptidase type 2 (MetAP2) is a metallo-enzyme considered today as an attractive target for the fight against cancer because its inhibition blocks the process of angiogenesis and therefore tumor progression. The aim of this work is to study the inhibition of MetAP II by molecular docking methods in order to discover new anti-angiogenic agents. FlexX is the molecular docking program used. Thus, this software allows predicting protein-inhibitor interactions. It was used to study the inhibition of 5JFR, a human MetAP II, by various molecules in order to discover the best inhibitors of this enzyme. The evaluation of the interaction energy of these inhibitors made it possible to identify those exhibiting the best inhibitory effect. These are compounds 6KP and A84, whose docking scores are -32.33 and -32.92 Kj/mol, respectively. The virtual screening of a similar collection of 370 of the compound 6KP and 139 of the compound A84 from PubChem revealed the compounds CID_66896495 and CID_11740546 as best inhibitors of MetAP II with an interaction energy equal to -40.27 KJ / mol for the first and -35.93 Kj / mol for the second. Finally, the Lipinski rule was performed to verify the pharmacokinetic properties of these two similar; they fit perfectly within the margin of the criteria imposed by Lipinski.
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