This paper presents the design of a fully integrated electrocardiogram (ECG) signal processor (ESP) for the prediction of ventricular arrhythmia using a unique set of ECG features and a naive Bayes classifier. Real-time and adaptive techniques for the detection and the delineation of the P-QRS-T waves were investigated to extract the fiducial points. Those techniques are robust to any variations in the ECG signal with high sensitivity and precision. Two databases of the heart signal recordings from the MIT PhysioNet and the American Heart Association were used as a validation set to evaluate the performance of the processor. Based on application-specified integrated circuit (ASIC) simulation results, the overall classification accuracy was found to be 86% on the out-of-sample validation data with 3-s window size. The architecture of the proposed ESP was implemented using 65-nm CMOS process. It occupied 0.112-mm 2 area and consumed 2.78-µW power at an operating frequency of 10 kHz and from an operating voltage of 1 V. It is worth mentioning that the proposed ESP is the first ASIC implementation of an ECG-based processor that is used for the prediction of ventricular arrhythmia up to 3 h before the onset.

The T and P waves of electrocardiogram signals are excellent indicators in the analysis and interpretation of cardiac arrhythmia. As such, the need to address and develop an accurate delineation technique for the detection of these waves is necessary. In this paper, we present a novel robust and adaptive T and P wave delineation method for real-time analysis and nonstandard ECG morphologies. The proposed method is based on ECG signal filtering, value estimation of different fiducial points, applying backward and forward search windows as well as adaptive thresholds. Simulations and evaluations prove the accuracy of the proposed technique in comparison to those proposed techniques in the literature. The mean error for the T peak, T offset, P peak and P offset values are found to be 9.8, 2.3, 7.3 and 3.5 milliseconds, respectively, based on the Physionet QT database, rendering our algorithm as an excellent candidate for ECG signal analysis.

Diabetes is characterized by high glucose levels in the blood that result from defects in insulin secretion, or its action, or both, being considered as one of the major contributors of precipitate infirmity and death in non-contagious diseases. Glucose meter is the prevailing technique to determine the glucose level, a technique involving chemical analysis of a sample of the diabetic blood obtained by pricking a finger. Yet, due to the many demerits of the glucose meter, including the pain and the direct contact requirement, many alternatives were proposed in the literature. In this paper, we explore and compare, based on a number of performance metrics, some of those techniques and systems and their compatibility to be implemented for Systemon-Chip (SoC) for glucose and health monitoring, which will potentially transform the future of healthcare by enabling proactive personal health care and ubiquitous monitoring of a patient's health profile and condition. A preliminary SoC design for non-invasive glucose monitoring is proposed

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