Previous research has identified patterns of cognitive deficits in patients with Alzheimer disease (AD), but little is known about their pattern of daily functional impairment. A total of 49 patients with AD and 52 healthy elderly controls were administered neuropsychological tests as well as the Direct Assessment of Functional Status (DAFS) test, an observation-based test of activities of daily living (ADLs). In this project, we assessed 14 separate tasks assessed by the DAFS. To analyze the data, 4 cognitive domains were created using neuropsychological composite z scores (means and standard deviation obtained from control data) for patients with AD. Results revealed that patients with AD performed worse on the memory, language, and visual-spatial relative to the executive domain. Additionally, patients with AD performed poorer than the controls on nearly all 14 DAFS tasks, with their worse performance being on the shopping-related tasks which, in part, requires memory skills. Logistic regression revealed better specificity than sensitivity classifications based on the DAFS tasks, and stepwise regression analyses indicated that cognitive domains predicted specific aspects of functional abilities. These findings suggest that patients with AD display a distinct pattern of ADLs performance, that traditional neuropsychological tests are useful in predicting daily functioning, and the DAFS has some strengths and weaknesses in classifying AD and controls.

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study and analyze the clinical course of cavernous sinus thrombosis in patients who underwent Covid-19 MethodsClinical analysis performed in 52 patients who applied to the multidisciplinary clinic of Tashkent Medical Academy over a period of 10 months. The mean age of patients was 60 ± 3.5 years, of them 28 women (53.8%) and 24 men (46.2%). The patients were hospitalized 1-2 month after infection, all tested positive for coronavirus (PCR, IFA). Clinical and laboratory examination of the patients, MRI-angiographic studies, medical history, complaints, and diagnosis were performed. ResultsAccording to analysis, septic cavernous sinus thrombosis was 75-80% and aseptic cavernous sinus thrombosis was 20-55%. Notably, the predominance of neurological symptoms in patients was unilateral in the head and face, unilateral chronic hemorrhagic sinusitis, and unilateral eye socket syndrome, loss of eyesight. In patients, despite complex treatment, the inflammatory process was chronic. In the process of inflammation we noted 38% of cases of soft tissue phlegmon, 70% of cases of transient necrosis with aseptic inflammation of the upper jaw, 55% of cases of orbital phlegmon (pictures). Patients complained of headache (85%) and general weakness (77%), discomfort (72%), loss of sensitivity in face -70%, mouth cramps (100%), facial nerve palsy (65%). Conclusionsin complication in patients with Covid-19 cavernous sinus thrombosis the process is characterized by progressive development on one side of the head and face. Complex treatment of patients requires multidisciplinary rehabilitation measures.