Objectives: Middle East respiratory syndrome Coronavirus (MERSCoV) is an epidemic in Saudi Arabia. This study aimed to measure the level of knowledge, attitude and practice about Coronavirus, to correlate the sociodemographic characteristics to the level of knowledge, attitude and practice about Coronavirus, and to explore awareness and health behaviors related to the prevention of Coronavirus.Method: A national adaptive cross-sectional survey conducted on 714 Saudi Arabian population aged from twenty to above sixty years old in period from March to April 2017. A standardized, confidential, Internet questionnaire used for a large randomly selected population in all regions of Saudi Arabia. Results: Out of 714 participants, women demonstrated a greaterlevel of knowledge of MERS-CoV risk and prevention than men. Social media was the main source for providing information about MERSCoV with (9.7%) excellent, (72.4%) fair and (17.9%) poor knowledge. Most participants had a good attitude toward privation of camel's milk and meat if they are source of transmission of MERS-CoV. However, females had better attitude toward the privation of camel's milk and meat (81.6%, p ≤ 0.001) than males (66.7%). Regarding safety precautions, the data suggested that males were significantly less than females in taking safety precautions and prevention by 0.563 time (OR: 0.563 (0.341-0.94), p≤ 0.05).