To evaluate the efficacy of transbronchial lung biopsy in the diagnosis of sarcoidosis, 26 consecutive patients with clinical features of sarcoidosis underwent this procedure during fiberoptic bronchoscopy. In 21, the biopsy revealed noncaseating granuloma and, in the remaining five, normal lung parenchyma. Subsequently, two of these five patients were found to have tuberculosis, one was confirmed as having sarcoidosis, and the fifth has not had further evaluation. Transbronchial lung biopsy was therefore successful in the histologic confirmation of sarcoidosis in 21 of 23 patients. The only complication was one 20 per cent pneumothorax, which resolved spontaneously. Because of its low morbidity rate, high diagnostic yield and specificity transbronchial lung biopsy is recommended as one of the initial procedures for obtaining histologic confirmation in patients with suspected sarcoidosis.
The uptake by the choroid plexus of adult rats of intravenously injected horseradish peroxidase has been investigated by electron microscopy. Within 4 min, the injected protein passes the capillary and is rapidly distributed through extracellular space and choroidal cells. Peroxidase enters the choroidal cells within coated vesicles which act as pinocytotic vesicles. At 15 min, peroxidase activity is present in numerous membrane-bound vesicles, multivesicular bodies, dense bodies and what appear to be segments of smooth endoplasmic reticulum. None of the peroxidase-containing organelles is seen to empty to the ventricular surface. Egress of the extracellular peroxidase into the cerebrospinal fluid is apparently blocked by apical zonulae occludentes between the choroidal cells.
The case of a 66-year-old man with pseudotumor of the spleen is presented. This rare entity can mimic malignant lymphoma clinically and radiographically. Splenectomy is diagnostic and curative. The etiology of pseudolymphoma is unknown, although a review of the literature suggests an association with prior systemic bacterial infection, as in the present case. Cancer 66:597-600,1990.NFLAMMATORY PSEUDOTUMOR (plasma cell granu-I loma) is a rare mass lesion with histologic features of inflammation and mesenchymal repair that has been observed in tissues of the respiratory tract,' gastrointestinal tract,2 orbit,3 soft tis~ues,~ lymph nodes,' and other organ^.^.^ When the lesion occurs as a primary splenic tumor, lymphoma is usually suspected clinically, and the true diagnosis is revealed only after the spleen is examined histologically. We recently observed a patient with this entity who has remained disease-free 24 months after the splenectomy. Case ReportA 66-year-old man was admitted to his community hospital in May 1988 with fever, pneumonia, hepatitis, and anemia. The liver was palpable two to three fingerbreadths below the costal margin but was not tender. A chest radiograph showed bilateral interstitial pneumonia involving all lobes except the right upper lobe, as well as small bilateral pleural effusions. An abdominal CT scan revealed mild splenomegaly and two right renal cysts.A diagnosis of Legionella pneumonia was made from sputum cultures and the patient responded to appropriate antibiotic therapy. However, hepatitis and malaise persisted and the patient was readmitted 1 month later for further evaluation. Significant physical findings were limited to jaundice and a nontender, palpable liver edge. The patient gave a history of jaundice that was treated medically at another hospital 10 years previously. He occasionally took indomethacin or ibuprofen for knee pain. Except for an appendectomy 40 years previously he had no other significant medical history. There was no history of blood donation or transfusion. The hematocrit was 30%, hemoglobin 9. gm/dl, and the platelet count was 377,OOO/pl. The leukocyte count was 12,9OO/p1 and a shift to the left was noted on a differential leukocyte count. The total serum bilirubin was 2.7 mg/ dl with a direct bilirubin of 1.4%. Serum alkaline phosphatase was 54 1 IU/l, SGOT 60 IU/l, SGPT 59 IU/l, and GGTP 52 1 IU/I. The blood urea nitrogen was 19 mg/dI and serum creatinine was I .2 mgdl. Hepatitis A antibody and hepatitis B surface antigen tests were negative. A bone marrow biopsy was hypercellular and an aspirate revealed mature granulocytic hyperplasia, moderately increased mature plasma cells, and decreased erythrocyte precursors.A repeat abdominal CT scan showed hepatosplenomegaly and a 10 cm focal solid splenic mass (Figs. 1 A and 1B). A comparison with the previous CT scan showed that the mass was barely perceptible on the previous scan. Furthermore, re-evaluation of a radionuclide bone scan done 6 months earlier for arthritic complaints revealed a suggestion of a...
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