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Public reporting burden for this colleOtion of information is estimated to average 1 hour per response, including the time for reviewing instru data needed, and completing and reviewing this collection of information Send comments regarding this burden estimate or any other asp this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0181 4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing t( valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM PuwiCThe U.S. Government is authorized to reproduce aid distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. SUPPLEMENTARY NOTES ABSTRACTUsing representative human nasal, oral and tracheobronchial airway models, transient 3-D as well as equivalent steady-state solutions have been obtained for the transport and deposition of spherical particles and droplets as well as vapors. It should be noted that equivalence to transient airflow and particle deposition results was achieved by employing matching Reynolds and Stokes numbers for steady-state simulations. Inhalation inlet conditions and aerosol characteristics resembled JP-8 fuel exposure scenarios in most case studies. Specifically, the following major tasks have been accomplished: (i)Airflow and transport/deposition of micron-and nano-size aerosols in representative human nasal airways; (ii) multi-component and/or impure droplet evaporation or hygroscopity; (iii) deposition differences between fuel aerosols (i.e., droplets) vs. vapors; (iv) studies of JP-8 fuel vapor transport and deposition by considering airway wall absorption; and (v) optimal drugaerosol targeting.The 3-year-project results are documented in 17 peer-reviewed journal articles (14 published and 3 accepted or submitted) and 9 conference papers/presentations. The often quoted articles have a significant impact on toxic/therapeutic aerosol research worldwide.Furthermore, in conjunction with other AFOSR-funded scientists, this work contributes to the understanding or health ettects ot inhaled JP-8 tuel aerosols and possible remedies, both
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