These data confirm the presence of cognitive impairment in 50% of patients with ALS and particularly implicate executive dysfunction and mild memory decline in the disease process. More severe impairment occurs in a subset of patients with ALS and has features consistent with FTD.

Objective-To determine the prevalence and correlates of neuropsychological impairment in a large cohort (n =

Risk of dementia by age 80 was more pronounced for Hispanic and black men compared with white men. IVD was the predominant cause of dementia among both black and white men. Grouping Hispanics with whites may mask differences when studying dementia.

No abstract

Background: The apolipoprotein E ε4 (APOE ε4) allele is associated with an increased risk of developing Alzheimer disease (AD). However, findings regarding an association between the APOE ε4 allele and the rate of decline in AD have been mixed. Objective: To examine the relationship between the APOE ε4 allele and the rate of cognitive and functional decline in AD using individual growth curve analyses.