For clarification of the in vivo antioxidant effect of sesame extracts (rich in lignan glycosides) on lipid peroxidation, determination was made of thiobarbitulic acid (TBA), phosphatidylcholine hydroperoxides (PCOOH) and hepatic activity of superoxide dismutase (EC 1.15.1.1; SOD). Male wistar rats were fed experimental diets containing sesame extracts for 2 week and killed 24 hours after injection of diethyldithiocarbamic acid (DDC), an SOD inhibiter. Blood and livers were then collected and hepatic TBA was determined 24 hour after DDC injection and the values were found significant. Heptic TBA of rats fed sesame extracts was significantly less than that of DDC injected rats. PCOOH in rats fed sesame extracts was about half that of DDC injected rats. Sesame extracts (rich in lignan glycosides) would thus appear to protect lipids from peroxidation in vivo.
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