The aim of the present study was to clarify relationships among the distribution of birth month, maturation and body size in young soccer players. We therefore examined physical and maturational differences between selected players, who were considered to have higher potential to play soccer at a professional level as decided subjectively by coaches, and unselected players. Participants were 332 elite soccer players (mean age = 12.2 +/- 1.5 years; range = 9.1-15.0 years). Participants were divided into six categories (under = U10 to U15), depending on chronological age. Height, body mass skeletal age and maturation difference (skeletal age - chronological age) were compared among four groups (quarter = Q1 to Q4) depending on month of birth. Overall, the distribution of players across the four quarters was skewed such that numbers were greatest in Q1 and smallest in Q4. No significant differences in maturation difference were observed between birth quarters in any age category. On the other hand, except for the U14 age category, there were no significant differences in height between Q4 and Q1 players. However, the height of Q4 players was significantly smaller than those of Q1 in three (U11, U13 and U14, P < 0.01) of six categories when maturation difference was statistically controlled. Our results suggest a clear bias toward quarter of birth and this bias may depend to some extent on differences in individual skeletal age and body size. Individual biological maturation should thus be considered when selecting adolescent soccer players.
Background: Throwing injuries of the shoulder and elbow are common among youth baseball players. Hypothesis: A prevention program will reduce the incidence of throwing injuries of the shoulder and elbow by 50% among youth baseball players. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: The authors block randomized 16 youth baseball teams consisting of 237 players aged 9 to 11 years into an intervention group (8 teams, 117 players) and a control group (8 teams, 120 players). The intervention program consisted of 5 stretching, 2 dynamic mobility, and 2 balance training exercises performed during warm-up. Both groups were followed up for 12 months, during which the incidence of shoulder and elbow injuries was recorded. In addition, ball speed during pitching as a performance-related factor and variables of physical function (passive range of motion of the elbow, shoulder and hip, dynamic balance, and thoracic kyphosis angle) were assessed during the pre- and postintervention periods. Results: The incidence of shoulder and elbow injuries in the intervention group (1.7 per 1000 athlete-exposures) was significantly lower than that in the control group (3.1 per 1000 athlete-exposures) (hazard ratio, 1.940; 95% CI, 1.175-3.205; P = .010). The factors related to pitching performance, as assessed by ball speed, tended to increase in the intervention group as compared with the control group ( P = .010). The program also improved shoulder horizontal adduction deficits on the dominant side, hip internal rotation on the nondominant side, and the thoracic kyphosis angle. Conclusion: A prevention program decreases throwing injuries of the shoulder and elbow and enhances the parameter of pitching performance in youth baseball players.
A prevention program aiming to improve physical function can prevent medial elbow injury in youth baseball players.
Objective. To determine the frequencies at which either a valine or leucine occurs at position 247 in the  2 -glycoprotein I ( 2 GPI) gene of normal individuals of the Caucasian, African American, and Asian ethnic groups and to compare these data with those in patients with the antiphospholipid syndrome (APS), with and without anti- 2 GPI antibodies.Methods. The DNA segment containing the position-247 polymorphism was amplified by seminested polymerase chain reaction, and the polymorphism was detected by restriction endonuclease digestion. DNA samples from 370 healthy controls of different racial backgrounds were analyzed, and the results were compared with those from 149 APS patients (66 primary; 83 secondary). Allele and genotype frequencies were compared using Fisher's exact test. When significant differences were detected, pairwise comparisons were made using Fisher's exact test with a Bonferroni adjustment.Results. Allele and genotype expression was significantly different (P < 0.0001 for both) among the 3 races, with the V allele and the VV genotype occurring most often among Caucasians, less among African Americans, and least among Asians. Conversely, the V allele and the VV genotype were found more frequently among Asian APS patients than among controls (P ؍ 0.0028 and P ؍ 0.0023, respectively). No significant differences in allele or genotype frequencies were seen in comparisons of the Caucasian or the African American patients with appropriate controls. The differences in allele and genotype frequencies seen in the Asian APS patients were restricted to the anti- 2 GPI-positive patients (P ؍ 0.0018 and P ؍ 0.0005, respectively).Conclusion. In Asian patients with APS, expression of a V at position 247, especially in the homozygous state, is significantly associated with the presence of anti- 2 GPI antibodies and, therefore, can be viewed as a major risk factor in this ethnic group (odds ratio 9.19 and 16.33, respectively).Patients with the antiphospholipid syndrome (APS) develop thromboembolic events, recurrent fetal loss, or thrombocytopenia in the setting of characteristic autoantibodies. Although it was initially thought that these antibodies react directly with phospholipids, subsequent studies indicated that critical epitopes involve a number of phospholipid-binding proteins (1-5). The
The tyrosine phosphorylation cascade originated from Fcγ receptors (FcγRs) is essential for macrophage functions including phagocytosis. Although the initial step is ascribed to Src family tyrosine kinases, the role of individual kinases in phagocytosis signaling is still to be determined. In reconstitution experiments, we first showed that expression in the RAW 264.7 cell line of C-terminal Src kinase (Csk) inhibited and that of a membrane-anchored, gain-of-function Csk abolished the FcγR-mediated signaling that leads to phagocytosis in a kinase-dependent manner. We next tested reconstruction of the signaling in the membrane-anchored, gain-of-function Csk-expressing cells by introducing Src family kinases the C-terminal negative regulatory sequence of which was replaced with a c-myc epitope. Those constructs derived from Lyn and Hck (a-Lyn and a-Hck) that associated with detergent-resistant membranes successfully reconstructed FcγR-mediated Syk activation, filamentous actin rearrangement, and phagocytosis. In contrast, c-Src-derived construct (a-Src), that was excluded from detergent-resistant membranes, could not restore the series of phagocytosis signaling. Tyrosine phosphorylation of Vav and c-Cbl was restored in common by a-Lyn, a-Hck, and a-Src, but FcγRIIB tyrosine phosphorylation, which is implicated in negative signaling, was reconstituted solely by a-Lyn and a-Hck. These findings suggest that Src family kinases are differentially involved in FcγR-signaling and that selective kinases including Lyn and Hck are able to fully transduce phagocytotic signaling.
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