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Entomopathogenic fungi seem to be interesting as a source of biologically active compounds such as an insecticides1) and immunosuppressants2,3), because all insect orders are susceptible to fungal diseases. With the goal of finding novel bioactive compounds from fungi, we investigated metabolite diversity using an HPLC screening program. During the screening process, we isolated two novel metabolites named pyridovericin (1) and pyridomacrolidin (2) (Fig.

Sir: Many entomopathogenic fungi are presumed to cause host death through the inhibition of enzymes and interference with the regulatory system in the host by production of toxic fungal metabolites and pathogenic classified into five genera: Oomycota, Chytridiomycota, Zygomycota, Ascomycota, and Deuteromycota, and Deuteromycota seems to be preferred as a source of screening for new bioactive compounds from fungal metabolites as fungi can be cultured on artificial media. of Health, for assay for protein tyrosine kinase.

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Pyridovericin and Pyridomacrolidin: Novel Metabolites from Entomopathogenic Fungi, Beauveria bassiana.-Production, isolation, structure, and biological activities of pyridovericin (I) and pyridomacrolidin (II) are reported. Both compounds do not exhibit antimicrobial activity but they weakly inhibit protein tyrosine kinase. -(TAKAHASHI, S.; KAKINUMA, N.; UCHIDA, K.; HASHIMOTO, R.; YANAGISAWA, T.; NAKAGAWA, A.; J.