The data indicate that traumatic DAI results in mainly transient neuropsychological deficits. Focal frontal contusions result in more relevant deficits at outcome that affect behaviour and, thus, impair rehabilitation prognosis. It is concluded that even in clinically 'mild' TBI, prognosis and rehabilitation requirements should be established by early imaging and post-acute neuropsychological assessment.
This investigation evaluated the neuropsychological symptoms in the early posttraumatic period following blunt head injury and their correlation to routine imaging data in a consecutive series of TBI patients (Magdeburg Neurotrauma Databank). Of 135 consecutive patients, 68 could be assessed neuropsychologically 8-21 days after trauma. In 61 patients, routine clinical CT data were sufficient for neuroradiological analysis focusing on the presence or absence of CT signs of diffuse axonal injury (DAI) or focal traumatic injury. In these patients, the initial GCS score was significantly correlated with the presence of DAI but not with focal pathology. The presence of DAI was correlated with behavioral and cognitive symptoms of frontal lobe dysfunction, especially in interference tasks (Go/NoGO and Stroop reaction times) and semantic fluency. The presence of local frontal or temporal traumatic lesions was associated with deficits in concept formation, fluency tasks and behavioral symptoms, but not with increased interference. Patients with frontal contusions were impaired in a task of visuomotor planning and performance (Block design). Our data indicate that both traumatic DAI and focal lesions result in frontal lobe symptoms. We conclude that, even in clinically "mild" TBI, brain imaging should be used to identify patients with substantial brain damage. These should be assessed neuropsychologically for possible posttraumatic cognitive or behavioral impairment. In consideration of its easy accessibility, the refined use of the CT is considered a promising and valid tool for patient stratification. The application of MRI and biochemical markers may further improve prognostic predictions.
Differences in coping styles could be mainly related to age and social factors. Individual coping strategies seem only to be little related to the type of brain pathology.
Zusammenfassung: Auf der Basis einer retrospektiven Untersuchung von 175 Patienten, die im Laufe der letzten 4 Jahre mit der klinischen Verdachtsdiagnose einer Demenz in unserer Abteilung vorgestellt wurden, werden die neuropsychologischen Defizite verschiedener Patientengruppen mit Morbus Parkinson, Chorea Huntington (HD), Multisystematrophien, vaskulärer subcorticaler Encephalopathie, Normaldruck-Hydrocephalus und wahrscheinlicher Alzheimerscher Erkrankung (AD) verglichen. Die Ergebnisse zeigen bei allen Patientengruppen schwere Beeinträchtigungen in den Bereichen Aufmerksamkeit und exekutive Funktionen ohne signifikante Unterschiede zwischen den einzelnen Diagnosegruppen. Eine deutliche Clusterbildung in bezug auf stärkere Beeinträchtigungen zeigt sich hingegen bezüglich längerfristigen Gedächtnisleistungen (HD und AD) sowie bei aphasischen, sprachassoziierten und apraktischen Störungen (AD). Auf Basis dieser Befunde werden die möglichen Implikationen der neuropsychologischen Diagnostik für die Differentialdiagnostik der Demenz diskutiert.
Wenn Mütter während der Schwangerschaft oder nach der Entbindung psychisch erkranken, kann das schwerwiegende Folgen für sie und ihr Kind haben. Um den Betroffenen zu helfen, gibt es in der Klinik für Psychiatrie und Psychotherapie des Klinikums Magdeburg eine Mutter-Kind-Einheit. Das umfangreiche Therapiekonzept hilft den Patientinnen, ihre Erkrankung anzunehmen, Auslöser zu erkennen, die eigene Compliance zu erhöhen und eine positive Bindung zu ihrem Kind aufzubauen.
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