Introduction: Diabetes mellitus (DM) is well-known metabolic disorder, which causes serious effects on human health with its complications. Many mechanisms has been postulated to cause DM related complications. One of the main complications is neuronal damage, for which no proper preventive and curative therapies are available.
Methods: In this study the effects of Ginger, Nigella sativa, Punica granatum and Metformin were seen on the prevention and treatment of brain damage caused by diabetes mellitus in streptozotocin (STZ)- induced diabetes in rats. 50 adult Wistar albino male rats were used in the study, the rats were divided in 10 study groups. The body weight, serum glucose levels were measured, and histopathological examination was performed.
Results: In comparison to the diabetic control rats, significant increase in weight was found in animals of all the studied groups. Serum glucose levels reduced significantly in comparison to the STZ induced diabetic rats in all the animals. Histopathological examination showed prevention from brain damage and repair of the neuronal tissues by Ginger, Nigella sativa, Punica granatum and Metformin.
Conclusion: The studied substances were observed to possess preventive and curative effects on the brain damage caused by diabetes mellitus.
Aim of the work-This study aimed to investigate the histological and histochemical changes in the lung tissue of male albino rats post exposure to gamma radiation and the possible therapeutic effect of both olive leaf extract and bone marrow mesenchymal stem cells. Matrerial and methods-The current study was carried out on 40 adult male albino rats (Sprague dawely strain); they were divided equally into 5 groups (C group: control rats; O group : rats treated with olive leaves extract(15 mg /kg body weight/daily) ; R group: rats exposed to a single dose of gamma-radiation(3 Gy); RO group: rats of this group treated with olive extract 15 mg /kg body weight/daily one week before and one week after irradiation; RS group: rats of this group irradiated with 3Gy then treated with bone marrow mesenchymal stem cells (BMSCs) 3×10 6 cells/ml suspension through caudal vein about 5h post radiation exposure. Histopathological and histochemical changes were studied. Results-Rats exposed to gamma radiation showed numerous histological and histochemical changes, these changes were ameliorated by using either olive leaf extract or bone marrow mesenchymal stem cells. BMSCs showed more obvious therapeutic effect than olive leaf extract. Conclusion-The present work showed that olive leaf extract or bone marrow mesenchymal stem cells (BMSCs) have lung tissue radiotherapeutic effects against whole body gamma radiation in male albino rats.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.