In clinical practice, simvastatin is usually used in the treatment of dyslipidemia patients and those at risk of or with established cardiovascular disease. However, previous studies have shown that simvastatin has the potential to affect glycemic parameters as it reportedly reduced insulin secretion and sensitivity. The exact mechanism by which simvastatin affects glycemia is still unknown, but previous studies have postulated the involvement of the glucose-insulin secretion mechanism. This review focuses on the effects of simvastatin, either alone or in combination with other lipid lowering agents, antidiabetics and antihypertensives, on glucose homeostasis. Some studies have reported that simvastatin might impair the levels of glucose metabolism markers in the blood while others have reported no effect or improvement in glycemia.
Background: Diabetic patients are permitted to carry out devotion of fasting by following appropriate diet regimen, medication adjustment and recommended daily physical activity. Those who do not follow the medical guideline might increase the risk for acute complication associated with fasting. This study aims to evaluate the level of knowledge, attitude, and practice among diabetic patients on fasting during Ramadan at Hospital Tengku Ampuan Afzan (HTAA). Methods: A cross-sectional study was conducted, where 62 diabetic patients were involved in this study. Convenience sampling was applied, and the study was conducted at HTAA including medical ward, orthopedic ward, surgical ward, eye ward and diabetic clinic. The data were analysis by using one-way ANOVA. Results: There were significant association between level of education factor with the attitude and practice of the diabetic patients during Ramadan with the p-value is lower than 0.05. The mean of the one-way ANOVA for attitude and practice were increased from the lowest to the highest of education level. Meanwhile, for the other sociodemographic variables (such as age, gender and receive health education), there is no significant association (p>0.05) with the level of knowledge, attitude and practice among the diabetic patients. Conclusions: The level of education showing the significant association with the attitude and practice which it implies that those who have higher education background possessed better attitude and practice management of diabetic fasting during Ramadan.
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