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Study DesignFifty patients surgically treated for tethered cord syndrome (TCS) were retrospectively studied at Liaquat National Hospital, Karachi from 2010 until 2014.PurposeTo assess the common presentations of TCS in our part of the world and the surgical outcome of the different presentations.Overview of LiteratureTCS is a stretch-induced functional disorder of the spinal cord with its caudal part anchored by an inelastic structure, which results in characteristic symptoms and signs. Due to the variety of lesions and clinical presentations and the absence of high-quality clinical outcome data, the decision regarding treatment is difficult.MethodsFifty consecutive patients with TCS were reviewed retrospectively with a follow-up period of 12–48 months. The majority of the patients were 0-15 years of age with the mean age of 4 years. The presenting complaints and the associated pathologies were documented, and the patients were assessed using the new Karachi TCS severity scale for clinical assessment.ResultsEighty five percent of the patients with thickened filum terminale improved. Sixty six percent of the patients with diastematomyelia, 60% with lipoma and only 46% with myelomeningocele showed clinical improvement postoperatively. Sixty two percent of the patients who presented with paraperesis improved following surgery while 37% remained stable and only one patient deteriorated. Back and leg pain improved in 93% of patients and 50% of patients with urinary impairment improved.ConclusionsOutcome of patients with TCS varies according to pathology and severity of symptoms. Diastematomyelia and thickened filum had the best outcome. The Karachi TCS severity scale is a valid tool for future studies.

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AIMS Newly diagnosed brain lesions (NBL) on imaging can be either primary or secondary in nature. Of these, only secondary brain lesions routinely require a staging CT chest, abdomen, and pelvis (CTCAP). But owing to lack of clear guidelines, all NBLs usually receive a staging investigation. This leads to over investigation of primary brain tumors. We sought to identify predictors of secondary brain lesions using CT head alone to guide the selection of patients for a CTCAP. METHOD Patients with NBLs referred to a tertiary Neurosurgical centre were reviewed. For protocol creation, data was collected from patients referred between July to December 2020, potential predictor variables were identified. Potential candidate protocols identified were assessed in a protocol-testing stage using data from a different set of patients. Sensitivity, specificity, and area under the curve (AUC) values were computed for each protocol. RESULTS The protocol-creation stage included 222 patients. Multivariate logistic regression analysis identified candidate protocols. This identified the most sensitive predictors of metastatic disease as : a previous history of cancer, multiple lesions, lesion size <4cm, and infratentorial location. A final protocol identified was found to have a sensitivity of 99.1% (AUC 0.704). CONCLUSION The use of the above protocol derived from this study would reduce unnecessary CTCAPs by 37.5-40% overall. Patients who do not fulfil at least one of the above said criteria on the first assessment should not have a CTCAP initially. This protocol reduces the financial and time costs from unnecessary CTCAPs as well as reduces patient exposure to radiation and contrast.