Some studies indicated a relationship between increased serum levels of osteoprotegerin with arterial calcification and as a result, it leads to the risk of cardiovascular disease. In our study group we selected patients with osteoporosis, with similar age and body mass index for the assessment of the relationship between cardiovascular disease and osteoprotegerin serum level. We took into account the analysis of correlation and association between the presence of distinct patterns of atherosclerosis and associated diseases like high blood pressure, diabetes mellitus, low HDL cholesterol, increased LDL cholesterol, increased triglycerides and was the case of presence of any type of dyslipidemia, in case of pre-existent treatment. Objective of study was the assessment of osteoprotegerin value as predictive marker for cardiovascular and metabolic risk in osteoporotic patients. Our results showed significant correlations of parathyroid hormone, osteocalcin and biochemical markers of bone with glucose metabolism and lipid were found in our research, maintaining crosstalk between calcium and biochemical markers of bone and cardiovascular risk. The serum level of Osteoprotegerin has been shown to have a large predictive value for the metabolic syndrome as a cardiovascular risk standard in patients with osteoporosis. The osteoprotegerin serum levels were increased in the patients with metabolic syndrome as a protective response facing the atherosclerotic lesions.
Polycystic ovarian syndrome is the most common reproductive endocrine disorder in premenopausal women Given the clinical overlap between PCOS and type 2 diabetes mellitus (T2DM), this research sought to investigate if genes associated with T2DM were similarly connected to PCOS vulnerability. In either the univariate or multivariate scenario, none of the 16 SNPs was significantly associated with Polycystic Ovarian Syndrome after Bonferroni correction for multiple testing. The nine T2DM genes investigated in this preliminary research may not be the main PCOS risk factors in Indian women. Our findings add to the absence of evidence of a link between T2DM genes and PCOS in Chinese and Caucasians, suggesting that this trend may be universal. To determine the exact significance of the diabetes genes, researchers will need to conduct extensive studies that involve women with T2DM and PCOS.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.