Ashwagandha formulations are used daily by the patients suffering from general disability and to promote vitality. In the present research work Ashwagandha formulation marketed in Yavatmal India were determined for the presence of microbial content. The specific Medias were used for determining the presence of Escherichia coli, Staphylococcus aureus, and P. aeruginosa. The W.H.O limits for microbial content is followed while determination. The total ten Ashwagandha formulation of various brands were selected randomly and tested for presence of microbial contamination as per W.H.O. The data indicated suggest that there was presence of Escherichia coli (3 samples), Staphylococcus aureus (4 samples), and P. aeruginosa (4 samples) were contaminated. It can be considered that the GMP was not followed properly while manufacturing and storage condition may not be maintained during transit of formulations. The results are expressed in Table No DiscussionThe present study reports microbial contaminations in herbal products widely distributed over the country. It was found that the formulations code H2, H3, H4 and H10 were contaminated by Pseudomonas aeruginosa and H3, H4, and H10 were contaminated by Escherichia coli whereas the formulations having code no H2, H3, H5 and H6 were contaminated by Staphylococcus aureus more than the limit prescribed by WHO if such product was consumed by patient there was possibility of infection. Medicinal plants have been generally used for decades. Consumers can easily acquire pathogenic microorganisms by consuming contaminated products. The results from this study suggest that the production of herbal products is still in critical situation in terms of quality and safety. Very low product quality can be derived from many factors such as cultivation, harvest, manufacturing procedure, transportation, and storage. The good handling must be carried out starting from raw materials to finished products.
The majority of people use toothpaste regularly.Typically, tootpaste is used to clean the mouth and teeth. It is also used to treat a variety of dental conditions. A lot of dentists advise using toothpaste to cure conditions including sensitivity and chronic gingivitis, among others. Herbal extracts of numerous crude medications with antibacterial and antimicrobial properties can be used to make herbal toothpaste. Herbs like ginger, indica extracts, babul leaves extract, ginger extract, lemon oil extract, neem stem & bark, babul leaves, gauva leaves, kalmi bark, etc. are used in the preparation of herbal toothpaste formulations. [1] Preparing, assessing, and contrasting lab-made herbal toothpaste with commercial herbal toothpastes is the major goal of the current effort. Commercial herbal toothpastes including Himalaya, Meswak, and Dent County have all had their quality assessed in the current study. All of the examined commercially available herbal tooth pastes and lab-made herbal toothpaste met the requirements outlined by the Bureau of Indian Standards. [2] The goal of the ongoing research is to create herbal toothpaste using chemicals like camphor, honey, and plant extracts including neem, tulshi leaves, and guava leaves. In formulating herbal toothpaste, characteristics like colour, spreadability, foamability, and particle identification of shard and edge abrasives were assessed. [3] Neem, Clove, Betel, Peppermint, Turmeric, and Guava are six plant samples included in this experiment that are typically used as traditional medicines. The created toothpastes were assessed in accordance with Bureau of Indian Standards requirements. The effectiveness of the tested toothpastes’ antibacterial properties was found. [4] One of the most important needs for humans is oral hygiene. Oral hygiene is the first step in a human being’s daily life. Therefore, toothpaste is crucial to this process. To counteract some drawbacks of synthetic cleaning agents, many natural herbs might be used. [5].
Transdermal drug delivery system is an essential part of novel drug distribution system. The topically administered medications in the form of patches which when applied to the skin deliver the drug .For operative TDDS the drug are easily able to penetrate the skin and easily reach the target site. TDDS avoids the first pass metabolism, less frequency of administration, reduction gastrointestinal side effects. Adverse effects are minimized due to steady and optimum blood concentration. It has greater bioavailability and efficacy of drug. The human skin is multi-layered organ composed of many histological layers. Skin is the largest organ in the body. Its major functions are protection of major or vital internal organs for the external influences, temperature regulations, control of water output and sensation. Polymer should be chemically non-reactive, should not decompose on storage, should be non-toxic, cost should not be high. E.g. - cellulose derivatives, zein, gelatin etc. Backing films play a vital role in the transdermal patch and the role of the film is to protect the active layer. Transdermal patches can be evaluated by interaction studies thickness, weight uniformity, drug content, in vitro study,moisture content, swelling index basic component of TDDS.
Oral drug carriers remain the most popular path for the delivery of drugs to date as it contains various advantages over any other delivery of therapeutics, despite a few disadvantages related to a particular category of sick people, along with elderly, neonatal, and dysphasic patients who struggle swallowing or chewing solid dosage forms because they are affiliated with many medical conditions. These sufferers also along with those who suffer from a range of infections. Many patients, both young and old, avoid taking solid drugs out of fear of choking. Even with fast dispersing pills, there is a risk of swallowing because of the tablet-like design. These patients also include those who are afflicted with many medical conditions.
Adverse Drug Reaction is the process that it involves the unaffected and undesirable effects of medication that used during normal clinical use. Adverse drug effects are normal some time but at some case there are some very serious adverse effects that can be very hazardous can be life threatening Adverse medication responses may make patients feel uneasy or untrusting of their doctors, leading them to look for other forms of self-care, which may lead to more adverse drug reactions (ADRs). In this review article it includes all introduction of the Adverse drug effects and mainly there is Focus on the biological hazard effects. Review article is based on the introduction of adverse effects of Drug some relevant definition and terms. The classification of ADR is done different types are enlisted in the review article. The all articles are about the ADR detection, identification and prevention. It also includes the relevant casualties assessment overview done by the WHO-UMC Monitoring Centre. In this the review of market greatest Risk factor are assessed by the monitoring center and further the methods for prevention of the ADR are suggested. If any ADR is reported, then all relevant information is collected by using questionnaire introduced in this review. My overall intention for choice of the reviewing the article is just to introduce the termpharmacovigilance and ADR in detailed and deep manner. the pharmacovigilance term is very important in market sector of view because it defines the performance of the product on human life.
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