Background: The process of embryo development requires the contribution of both male and female gametes. However, abnormal sperm development can hinder the fertilization process, leading to infertility. To overcome these male fertility issues, intracytoplasmic sperm injection (ICSI) was developed. This technique has proven to be effective, resulting in about 80% of live births in ICSI cycles.
Methods: It is a retrospective cohort study was conducted in department of reproductive medicine, Komali fertility centre a unit of Dr. Ramesh Cardiac and multispeciality hospital P Ltd, Guntur, Andhra Pradesh, India. The study was conducted during period of January 2022 to December 2022. Total 120 subjects were included based on our inclusion and exclusion criteria.
Results: This study used the chi-square test and Pearson's correlation to evaluate the relationship between sperm morphology and various parameters, revealing that poor sperm morphology may contribute to low fertilization, cleavage, and pregnancy outcomes. Individuals with 3% sperm morphology exhibited higher mean fertility rates and lower negative pregnancy rates compared to those with 2% and 1% morphology, highlighting the importance of good sperm morphology for successful fertilization and pregnancy outcomes.
Conclusions: In summary, the study highlights a strong correlation between sperm morphology, fertilization and cleavage rates, while a weak and no correlation was observed between sperm morphology and pregnancy outcome after ICSI. The findings suggest that an improvement in sperm morphology leads to increased fertilization and cleavage rates.
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Adenomyosis and uterine leiomyoma are benign lesions of the myometrium. Adenomyosis is a myometrial lesion characterised by the presence of ectopic endometrium with or without hyperplasia of the surrounding myometrium. Uterine fibroids, also called leiomyomas or myomas, are benign tumours that arise from the smooth muscle of the uterus. A 33-year-old nulliparous woman attended the clinic with primary infertility for 18 years. She was diagnosed with severe adenomyosis and uterine fibroids. She conceived successfully after undergoing in vitro fertilization (IVF) and a downregulated frozen embryo transfer (FET). Adenomyosis is a common cause of primary and secondary dysmenorrhea associated with infertility in young, nulliparous women. Fertility preservation is the primary goal in this population. Medical management is essential, and a properly downregulated and planned FET is the treatment of choice.
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