Cypermethrin (CYP) is a popular environmental toxicant because of its wide-ranging use as a broad-band insecticide. The purpose of this research was to explore the potential impact of Moringa oleifera leaves extract (MOLE) as a protective agent against cypermethrin-induced lung toxicity in male albino rats. Forty experimental animals were allocated into four groups. G1 served as the negative control, G2, G3 and G4 were orally treated with MOLE (250 mg/kg body weight), CYP (26.15mg/kg body weight) and CYP + MOLE, respectively. CYP oral administration for 28 days elevated the levels of oxidative stress biomarkers like Malondialdehyde, superoxide dismutase, catalase and glutathione S-transferase and caused a decline in the content of reduced glutathione in the lung tissue of the rats. Lung injury was verified by histopathological changes evidenced by interstitial pneumonia, marked perivasculitis, focal pulmonary hemorrhage, haemosidrosis and pulmonary edema in CYP-exposed rats. Co-administration of MOLE mitigated the induced oxidative stress and histopathological alterations. As a result, Moringa oleifera can prevent cypermethrin-induced lung toxicity due to its free radical scavenging and antioxidant properties.
Background: Since its first hit in 2019, pandemic has caused devastating consequences all over the globe. Serological testing can assess the level of humoral immune response and can guide for appropriate health decisions. Objective: This work aimed to test performance agreement between rapid tests and ELISA in serological detection of COVID-19 antibodies among generally randomized Egyptian participants. Methodology: Total 238 randomized Egyptian participants were serologically screened for SARS-CoV-2 IgM and IgG using COVID-19 IgM/IgG Combo rapid test and NovaLisa SARS-CoV-2 IgM and IgG ELISA kit in the period from March 2021 to June 2021 (pandemic third wave). Result: COVID-19 antibodies showed seroprevalence rate of 47.47%, distributed among symptomatic and asymptomatic individuals by rates of 51% and 42.5%, respectively. IgM and IgG antibodies had rates of 8.8% and 35.6%, while rates of 10.9% and 28.2% by ELISA respectively. The agreement between ELISA and rapid test was none to slight for IgM (p = 0.35), while fair for IgG; (p < 0.001). Conclusion: COVID-19 antibodies were positive in nearly half of enrolled participants. Rapid test showed fair agreement for IgG, while none to slight agreement for IgM with ELISA, thus can not replace ELISA in serological testing.
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