Synthetic Studies on Kinamycin Antibiotics: Elaboration of a Highly Oxygenated D Ring.-The first successful construction of a 3,4,5,6tetraoxygenated cyclohexene ring with the correct relative configuration (cis, trans, trans) in kinamycin skeletons is reported. Key steps of the synthesis are a highly endo-selective Diels-Alder cycloaddition of (I) and diene (II) and the stereoselective dihydroxylation of tri-Tbs-ether (VIII) affording triol (IX) with the desired relative configuration. -(KUMAMOTO, TAKUYA; TABE,
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