There are a substantial number of neonates who present with Hirschsprung's disease-like symptoms, but respond very well to conservative therapy. However, once Hirschsprung's disease is ruled out, little attention is paid to these infants, because of the lack of necessity for surgical treatment and their excellent prognosis. The purpose of this study was to elucidate the clinical features of functional ileus of neonates, which we named benign transient non-organic ileus of neonates (BTNIN). Out of 61 neonates referred to our institution with suspected neonatal Hirschsprung's disease (NH), 10 were diagnosed as having NH and 51 as having BTNIN. All the cases of BTNIN showed marked abdominal distension, and 12 showed explosive defecation on digital examination at the first visit. Plain X-ray demonstrated marked whole intestinal dilatation in 12 cases including cases with niveau formation and segmental dilatation. These findings were indistinguishable from those of NH. However, all had a normal anorectal reflex, and rectal suction biopsy revealed normal acetylcholinesterase activity and submucosal ganglion cells. All the cases of BTNIN were treated with periodic glycerin enemas until daily spontaneous defecation was established, which took 2 to 14 months, with an average of 5.0 +/- 2.9 months. None of them showed residual symptoms during the follow-up period.

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Clindamycin-2-phosphate is an injectable preparation of clindamycin which has a high antibacterial activity against gram-positive cocci and anaerobic bacteria. The purpose of the present study was to evaluate the effect of the drug in the clinical treatment of various otorhinolaryngological infection.Fourty-seven out of 64 patients with suppurative otitis media were treated successfully, i.e., evaluated as good or excellent (efficacy rate was 73.4%). Similarly, 15 out of 26 patients with paranasal sinusitis (57.7%), all nine patients with peritonsillar abscess (100%), 14 out of 15 patients with acute tonsillitis (93.3%) and 7 out of 8 patients with other diseases such as acute pharyngitis, etc. (87.5%), were successfully treated.Side effets were observed in one patient with pain at injection site, one with eruption with feeling of pruritus, and one with eruption (incidence of side effect was 2.5%; 4/158). None of the side effects were serious; all of them cleared in 2 to 4 days. Among abnormal laboratory findings observed were an increase in GOT and GPT, urinary protein, an increase in BUN, and leukocytosis; none of them were particularly serious.