This case-control study sought to confirm the exploratory finding of an association between polycystic ovary syndrome and risk of pancreatic cancer.

Endometrial cancer (EC) incidence is on the rise. Although early-onset endometrial cancer (EOEC, age at diagnosis <50) is relatively uncommon, the incidence of EOEC has been reportedly increasing in recent decades. However, the rising EOEC has not been thoroughly described with regard to the racial/ethnic disparities and in comparison with the late-onset EC (LOEC, age at diagnosis ≥50). We used the CiNA Analytic File, 1995-2018, from the North American Association of Central Cancer Registries (NAACCR), which allowed us to examine trends in invasive EC incidence by racial/ethnic groups and by age at diagnosis. We found striking differences for demographic and tumor characteristics as well as racial/ethnic patterns and time trends in EC incidence between EOEC and LOEC. The faster increases in EOEC incidence rates, especially among non-White women, mirror similar observations in other cancers pointing to a possible link with rising obesity epidemic in younger generations.

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