Curcumin loaded poly(2-hydroxy ethyl methacrylate) p(HEMA) nanofiber were produced using electrospinning method and characterized. The nanofibrous scaffold supports good cell growth, attachment and retains its original morphology. Sustained and controlled release pattern of curcumin seen to be efficient against infectious disease caused by multidrug resistant organisms. Antibacterial activity of curcumin against Methicillin resistant staphylococcus aureus (MRSA) and extended spectrum β lactamase (ESBL) proved to be a good alternate herbal compound for antibiotics. Hence the results indicate p(HEMA) nanofiber loaded with curcumin have potential to use as patch in wound healing of infectious disease caused by multidrug resistant organisms and excellent drug delivery vessel.
ABSTRACT:Electrospinning is a reliable method to produce polymer nanofibers for medical applications. In this report, poly(2-hydroxy ethyl methacrylate) (p(HEMA)) was electrospun using ethanol and water (4:1) to produce nanofibers. Electrospinning parameters such as the polymer concentration, flow rate, electric field, and distance between needle and collector were optimized. Nanofibers with diameters ranging from nano-to micrometer were obtained as seen through a scanning electron microscope. Solvent evaporation, thermal stability, crystallinity, storage modulus, and viscoelastic behavior were analyzed using FTIR, thermal analysis, X-ray diffraction, and dynamical mechanical analysis respectively. This polymer fiber with mechanical strength, high swelling ratio, and good cell viability is shown to be an excellent biocompatible polymer for tissue engineering applications. C
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