We set out to determine which characteristics and outcomes of stroke are associated with COVID-19. Methods This case-control study included patients admitted with stroke to 13 hospitals in England and Scotland between 9 th March and 5 th July 2020. We collected data on86strokes (81 ischaemic strokes and 5intracerebral haemorrhages)in patients withevidence of COVID-19 at the time of stroke onset (Cases). They were compared with 1384strokes(1193 ischaemic strokes and 191 intracerebral haemorrhages) in patients admitted during the same time periodwho never had evidence of COVID-19 (Controls). In addition the whole group of stroke admissions, including another 37 in patients who appear to have developed COVID-19 after their stroke, were included in two logistic regression analyses examining which features wereindependently associated with COVID-19 status and with inpatient mortality. Results Cases with ischaemic stroke were more likely than ischaemic controls to occur in Asians (18.8% vs 6.7%, p<0.0002), were more likely to involve multiple large vessel occlusions (17•9% vs 8.1%, p<0•03), were more severe (median NIHSS 8 vs 5, p<0•002), were associated with higher D-dimer levels (p<0•01) and were associated withmore severe disability on discharge (median mRS 4 vs 3, p<0•0001) and inpatientdeath (19.8% vs9•6%, p<0•0001). Recurrence of stroke during the patient's admission was rare in Cases and Controls (2.3% vs1.0%, NS). Conclusions Our data suggest that COVID-19 may be an important modifier of the onset, characteristics and outcome of acute ischaemic stroke.

Introduction The coronavirus disease (COVID-19) pandemic has changed routine clinical practice worldwide with major impacts on the provision of care and treatment for stroke patients. Methods This retrospective observational study included all patients admitted to the Royal Stoke University Hospital in Stoke-on-Trent, UK, with a stroke or transient ischaemic attack between March 15th and April 14th, 2020 (COVID). Patient demographics, characteristics of the stroke, treatment details and logistics were compared with patients admitted in the corresponding weeks in the year before (2019). Results There was a 39.5% (n = 101 vs n = 167) reduction in admissions in the COVID cohort compared with 2019 with more severe strokes (median National Institutes of Health Stroke Scale (NIHSS) 7 vs 4, p = 0.02), and fewer strokes with no visible acute pathology (21.8 vs 37.1%, p = 0.01) on computed tomography. There was no statistically significant difference in the rates of thrombolysis (10.9 vs 13.2%, p = 0.72) and/or thrombectomy (5.9 vs 4.8%, p = 0.90) and no statistically significant difference in time from stroke onset to arrival at hospital (734 vs 576 min, p = 0.34), door-to-needle time for thrombolysis (54 vs 64 min, p = 0.43) and door-to-thrombectomy time (181 vs 445 min, p = 0.72). Thirty-day mortality was not significantly higher in the COVID year (10.9 vs 8.9%, p = 0.77). None of the 7 stroke patients infected with COVID-19 died. Conclusions During the COVID-19 pandemic, the number of stroke admissions fell, and stroke severity increased. There was no statistically significant change in the delivery of thrombolysis and mechanical thrombectomy and no increase in mortality.

No abstract

No abstract