An association between chronic inflammatory prostate and periodontal diseases has been demonstrated by the presence of similar bacterial DNA in both prostatic secretion and subgingival dental plaque from the same individual.
was to assess whether non-surgical periodontal treatment has an effect on prostate symptom score and serum PSA and levels of proinflammatory cytokines, viz., IL-1β and CRP in men with elevated serum PSA and chronic periodontitis.
There were 25 patients and 24 controls with complete data. Mean ages were similar (CPPS 52.3 vs control 57.0 years, p¼0.27). For patients, median symptom duration was 48 months, mean CPSI was 26.0 and mean number of UPOINT domains was 3.6. 3D Unifrac PCoA revealed tighter clustering of controls in a space distinct from the wider clustering of cases (corrected P¼0.001; a-diversity P¼0.001). Compared to controls, 5 operational taxanomic units were over-represented, eg, Varibaculum, and 80 under-represented, eg, Prevotella, in cases. There was a trend in microbiomic differences with the neurologic/systemic phenotype for CPPS patients (p¼0.2). Finally, in silico characterization by PiCRUSt showed specific pathways, such as ribosomes and pyrimidine transporters, and purine and thiamine metabolism, were under-expressed in patients CONCLUSIONS: CPPS patients have significantly lower alpha diversity of gut microbiome which cluster differently from controls, and higher counts of Varibaculum, with separation sufficient to serve as a potential biomarker. The gut microbiome may serve as both biomarker of disease and potential target for therapy in CPPS.
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