The Gorlin-Goltz syndrome (GGS) (the nevoid basal cell carcinoma syndrome) is a rare autosomal dominant syndrome caused due to mutations in the patched gene found on chromosome arm 9 q. It shows high penetrance and variable expressivity; is characterized by basal cell carcinomas, odontogenic keratocysts, palmar and/or plantar pits and ectopic calcifications of the falx cerebri. Until date, very few cases of GGS have been reported in India. Early diagnosis and treatment as well as genetic counseling are essential for this syndrome. A rare case report of a patient with characteristic features of GGS diagnosed at a rural dental college of Gujarat, India is presented here. This case report draws attention of the valuable role of dentist in diagnosis and early management of this syndrome.
Original Research ArticleBackground: Ophthalmic pathology is subspeciality of pathology and ophthalmology that focuses on diseases of eye and its neighbouring tissue that ranges from benign to precancerous and malignant lesion. Aims and objective: To study morphological and clinico-pathological correlation of ophthalmic lesions and to enhance the commuinication between ophthalmic surgeon and histopathologist to get detailed information regarding patients'clinical history,signsymptoms and associated features so that we could correlate with histopathological features. Methods: This study was conducted in C. U. Shah Medical College, Surendranagar during year 2016-17. Total 50 specimens were received from ophthalmology department and studied for histopathology. Result: Out of 50 cases, 48.8% were benign, 14.89 % were malignant, 18.76% were inflammatory and 17.45 % were non-catagorised. Eyelid was the most common site (53.19%). Clinico-histopathological concordance was in approximate 69% cases and discordance was in 31% of cases. Out of these cases of discordance, 43% cases were found to be malignant and diagnosed by clinico-pathological correlation as malignancy was not evident clinically. Conclusion: All ophthalmic lesions removed surgically should always be subjected to histopathological examination to establish correct diagnosis and greatest benefit to ongoing patient care.
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