In patients with aorta-right atrial tunnel, 2-dimensional echocardiography and transesophageal echocardiography are enough to establish clinical diagnosis, but ascending aortography is necessary to differentiate from more common clinical conditions, like ruptured sinus of Valsalva aneurysm and coronary cameral fistula. The rarity of this condition is established by the fact that during the same period of time, we have treated in our institution 66 cases of ruptured sinus of Valsalva aneurysm, which is the most common aorta-right atrial communication. Treatment options are simple ligation or ligation with implantation of coronary ostium or coil embolization. The location of the coronary ostium dictates technical details. Follow-up reveals excellent functional recovery.
Hazardous health effects stemming from exposure to radiofrequency electromagnetic waves (RF-EMW) emitted from cell phones have been reported in the literature. However, the cellular target of RF-EMW is still controversial. This review identifies the plasma membrane as a target of RF-EMW. In addition, the effects of RF-EMW on plasma membrane structures (i.e. NADH oxidase, phosphatidylserine, ornithine decarboxylase) and voltage-gated calcium channels are discussed. We explore the disturbance in reactive oxygen species (ROS) metabolism caused by RF-EMW and delineate NADH oxidase mediated ROS formation as playing a central role in oxidative stress (OS) due to cell phone radiation (with a focus on the male reproductive system). This review also addresses: 1) the controversial effects of RF-EMW on mammalian cells and sperm DNA as well as its effect on apoptosis, 2) epidemiological, in vivo animal and in vitro studies on the effect of RF-EMW on male reproductive system, and 3) finally, exposure assessment and dosimetry by computational biomodeling.
SWI/SNF chromatin remodeling complexes regulate critical cellular processes
including cell cycle control, programmed cell death, differentiation, genomic instability
and DNA repair. Inactivation of this class of chromatin remodeling complex has been
associated with a variety of malignancies, including lung, ovarian, renal, liver and
pediatric cancers. In particular, ~10% of primary human lung non-small lung cancers
(NSCLC) display attenuations in the BRG1 ATPase, a core factor in SWI/SNF complexes. To
evaluate the role of BRG1 attenuation in NSCLC development, we examined the effect of BRG1
silencing in primary and established human NSCLC cells. BRG1 loss altered cellular
morphology and increased tumorigenic potential. Gene expression analyses showed reduced
expression of genes known to be associated with progression of human NSCLC. We
demonstrated that BRG1 losses in NSCLC cells were associated with variations in chromatin
structure, including differences in nucleosome positioning and occupancy surrounding
transcriptional start sites of disease-relevant genes. Our results offer direct evidence
that BRG1 attenuation contributes to NSCLC aggressiveness by altering nucleosome
positioning at a wide range of genes, including key cancer-associated genes.
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