Objectives:Wrightia antidysenterica Linn. (WA) is male variety Kutaja stated to be potent therapeutic emetic agent in skin disorders. Expulsion of doshas through oral route is termed as Vamana Karma (VK) (therapeutic emesis). However, so far, its utility for Vamana is not explored in detail, therefore there is a need to revalidate the utility of WA for Vamana. Hence, the above study was conducted to ascertain the efficacy as a therapeutic emetic agent (vamaka yoga) in the management of psoriasis along with quality control and standardization of this herb.Materials and Methods:The drug was standardized as per analytical procedures in Pharmacopeias. Thirty patients of psoriasis fulfilling inclusion criteria were taken for the study and Vamana with WA was conducted. Criteria were prepared to assess the signs and Symptoms of psoriasis. VK was assessed using the classical Lakshanas (features) such as Anthiki shudhi (Ending symptoms of emesis), Vaigiki shudhi (features of vomiting bouts), Maniki shudhi (Quantitative and qualitative purification), complications.Result:VK with WA showed significant relief in parameters of psoriasis such as scaling, itching, candle grease sign (P < 0.001), and psoriasis area and severity index score (P = 0.001). In VK with WA, mean number of Vegas (vomiting bouts) was 6.91. 66% patients showing quantitative purification between 301 and 600 ml. 73.33% showed all Symptoms of purification. 73.33% patients showed Kaphanta vamana (Moderate expulsion of desire humor). In the level of biopurification, 66.66% patients showed moderated purification. No complication was noted with moderate drug palatability.Conclusion:Pharmacopeial analytical study showed its standardized values for testing the drug used for the study. It is proved as potent therapeutic emetic agent with no complication showed its clinical benefits over skin disorder like psoriasis.SUMMARY Seeds of Wrightia antidysenterica (WA) Linn. free from any foreign matter were selected for the study. Loss on drying revealed 6.535% moisture content; total ash indicating of total inorganic content was found to be 5.12%; acid insoluble ash is the acid insoluble part of total ash, mainly silica, WA showed 0.393% acid insoluble ash; ethanol and water soluble extractive is indicative of percentage active constituents were found to be 25.66 and 20.854%, respectively. High-performance thin layer chromatography fingerprinting profiles of WA under 254 nm showed the presence of 7 spots (all in green) at Rf values ranging from 0.21 to 0.88. Under 366 nm there were 4 prominent spots (all in fluorescent) at Rf 0.49 to 0.82 and, when scanned under white light 620 nm following derivatization with vanillin sulfuric acid 6 spots (in different colors) were evident at Rf 0.28 to 0.58. Among these spot with Rf of 0.58 was common when visualized under all the three methods. Rf values by densitometric scan of WA showed 12 peaks at 254 nm and 5 peaks at 366 nm. However, in clinical trial, it was found to be a potent emetic agent without any complication. Abbreviati...
In modern era stress and faulty lifestyles leads to many diseases clubbed under Lifestyle disorders. Cardiovascular diseases (CVD) are one such disorder which has contributed heavily to mortality rate worldwide in young adults. Cardiovascular diseases are discussed in Ayurveda under Hridrogas. Panchakarma, the five bio-purifactory procedure of Ayurveda plays a pivotal role in the management of lifestyle disorders. Panchakarma by its Sodhana effect can treat the diseases from its very root. However, Hridrogas being acute medical emergency conditions Panchakarma is not prescribed as a treatment modality. However, Panchakarma can be practised in all conditions according to Rogibala and Rogaavastha. So there arises a need to practice Panchakarma according to classics in medical situations like Hridroga so that Panchakarma can be justified as a modality of management in various severe medical conditions in preventive and curative aspects.
The eternal science of life Ayurveda has indicated various types of Chikitsa for the management of diseases. Amongst the Chikitsa mentioned, Shadvidopakrama bears lot of significance. In this context the knowledge of upakrama becomes very essential. The Sadvidhaupakrama, the combination of six prime upakramas of Ayurveda can be considered a part of Yuktivipashraya chikitsa. Sadvidha upakrama plans to act by balancing the proportion of the Panchamahabhutas in the body. In other words those substances or process which increases the agni, vayu and aakasha mahabhuta in the body can be termed as langhana. Result of any Upakrama is Dosha Saamyata. It is attained through balancing the Gunas, ultimately by achieving the Panchabhouthika stability. Whatever may be the treatment modalities it will come under the peer view of Shadvidhopkrama. That is the reason these principles of shadvidhopkrama are implemented in the day to day clinical practice
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