FETTERLY, B. M.; JANA, N. K.; VERKADE*, J. G.; Tetrahedron 62 (2006) 2-3, p440-p456; Dep. Chem., Iowa State Univ., Ames, IA 50011, USA; Eng.) -Y. Steudel 22-033
A number of pyrrolo[3,2-d]pyrimidine
derivatives (5a
−
f) were synthesized
in 90−95% yields from
the corresponding
5-[N-[4-(aryloxy)but-2-ynyl]-N-ethylamino]-1,3-dimethyluracils
4a
−
f by simple
treatment with 1 equiv of m-chloroperoxybenzoic acid in
dichloromethane at 0−5 °C for 12−15 h.
The resulting benzoates (5a
−
f)
were easily converted to methoxy derivatives
11a
−
f in 92−94%
yields when refluxed in methanol for 20−22 h.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.