Rapidly progressing glomerulonephritis like microscopic polyangiitis and allergic granulomatous angiitis are among the common presentations of perinuclear antineutrophilic cytoplasmic antibody (p-ANCA) vasculitis. Involvement of central nervous system is rare in contrast to mononeuritis multiplex, which is a well-known neurological manifestation of this condition. We report a case presented with uraemic encephalopathy and posterior reversible encephalopathy syndrome (PRES)-related symptoms, which showed recovery after haemodialysis although PRES with seizures recurred later. As uraemic encephalopathy appears to be the underlying aetiology as per the temporal correlation of correction of uraemia and resolution of the symptoms of PRES, it becomes a rare case of uraemia-induced PRES as a presenting manifestation of p-ANCA-associated vasculitis along with necrotising crescentic glomerulonephritis.
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