Symmetrical 2,5-disubstituted thiophene derivatives containing 1,3,4-oxadiazole moiety bearing different aromatic substitutions were synthesized by employing convenient and simple synthetic protocols using thiophene-2,5,dicarboxylic acid as a starting material. The structures of these target molecules were established by their analytical and spectral data. The photophysical and electrochemical studies were carried out on these compounds and found that they exhibit good fluorescent properties with high quantum yield.
A series of novel unsymmetrical bithiophene substituted oxadiazole derivatives 2(a-e) were designed and synthesised by employing palladium catalysed Suzuki cross coupling reaction. These bipolar molecules consist of bithiophene as an electron donor unit (D) and electron transporting oxadiazole as acceptor unit (A). The structural integrity of all the new compounds was confirmed by 1 H NMR, 13 C NMR and LC-MS analysis. The photo physical and electrochemical properties have been studied in detail using UV-Vis absorption, fluorescence spectroscopy and CV measurements. All compounds emit intense green fluorescence with better quantum yields. Density Functional Theory computations have been carried out for the better understanding of structure-property relationship, the computed values are found to be in good agreement with the experimental results. The results demonstrated that the novel bithiophene containing oxadiazole derivatives could play important role in organic optoelectronics.
An efficient, simple and relatively inexpensive method for the synthesis of coumarins in aqueous sodium bicarbonate at ambient temperature has been developed. It features an intramolecular Wittig reaction of substituted 2-formylphenyl 2-bromoacetate in saturated aqueous sodium bicarbonate. Its advantages include benign reaction conditions, easy work-up and good overall yield with short reaction time.Various substituted coumarins have been synthesized by utilizing this methodology.
A novel series of 5-(2-alkyl/aryl-6-arylimidazo[2,1-b][1,3,4]thiadiazol-5-yl)methylene-1,3-thiazolidinediones were synthesized as possible PPARγ agonists. The structures of these target molecules were established by spectral and analytical data. All the newly synthesized compounds were screened for their in vivo hypoglycaemic and hypolipidemic activity in male Wistar rats. Further, compounds with good activity were screened for PPARγ agonist activity. Among the screened compounds, 5-{[2-Cyclohexyl-6-(4-methoxyphenyl)imidazo[2,1-b] [1,3,4]thiadiazol-5-yl]methylene}-1,3-thiazolidine-2,4-dione (3i) exhibits promising hypoglycaemic and hypolipidemic activity via potential PPARγ agonist activity.
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