ObjectiveTo compare the clinical outcomes of follicular versus luteal phase ovarian
stimulation in women with poor ovarian response (Bologna criteria)
undergoing IVF.MethodsThis retrospective study investigated 446 patients submitted to 507 cycles in
three groups. First, the two larger cohorts were examined: 154 patients
treated with luteal phase ovarian stimulation (Group Lu); and 231 patients
administered follicular phase ovarian stimulation (Group Fo). Then the
clinical outcomes of 61 patients submitted to double ovarian stimulation
were analyzed. Clinical outcomes included number of retrieved oocytes,
fertilization rate, cleavage rate, top-quality embryo rate, clinical
pregnancy rate (CPR), and live birth rate (LBR).ResultsLonger stimulation, higher dosages of HMG, and higher MII oocyte rates were
achieved in Group Lu (p<0.001). There were no
significant differences in CPR and LBR between the two groups offered
frozen-thawed embryo transfer (28.4% vs. 33.0%, p=0.484;
22.9% vs. 25.5%, p=0.666). In the double ovarian
stimulation group, the number of oocytes retrieved in the luteal phase
stimulation protocol was higher (p=0.035), although luteal
phase stimulation yielded a lower rate of MII oocytes
(p=0.031). CPR and LBR were not statistically different
(13.8% vs. 21.4%, p=0.525; 10.3% vs. 14.3%,
p=0.706).ConclusionLuteal phase ovarian stimulation may be a promising protocol to treat women
with POR, particularly for patients unable to yield enough viable embryos
through follicular phase ovarian stimulation or other protocols.
Polycystic ovary syndrome (PCOS) is currently considered a predominantly hyperandrogenic syndrome. In theory, hyperandrogenism can be caused by high level of testosterone (T) as well as by enhanced androgen receptor (AR) activity. C-Terminal binding protein 1 antisense (CTBP1-AS) was a novel long noncoding RNA (lncRNA) to regulate AR activity. In this study, we found that expression level of CTBP1-AS in peripheral blood leukocytes was significantly higher in women with PCOS than that in controls after adjustment for age and body mass index (BMI). Individuals having higher expression of CTBP1-AS had significantly greater disease risk than those having lower expression. We also identified expression of CTBP1-AS as an independent risk factor for PCOS. A positive correlation was observed between the CTBP1-AS expression and the total T (TT) concentration either unadjusted or after adjusting for age, BMI, and homeostatic model assessment insulin resistance. Taken together, our current study presented the first evidence that the lncRNA CTBP1-AS, a novel AR modulator, is associated with PCOS in Chinese population and established the possibility that abnormal CTBP1-AS expression is a risk factor for PCOS and it is a predictor of variability in serum TT level in Chinese women with PCOS.
Polycystic ovary syndrome (PCOS) has been recognized as a common reproductive and endocrine disorder. Long noncoding RNA (lncRNA) steroid receptor RNA activator (SRA) affects multiple biological processes. However, it is not known whether lncRNA SRA is associated with PCOS. In the study, we measured the expression level of lncRNA SRA in PCOS patients, and analyzed the association between lncRNA SRA and multiple key endocrine parameters of PCOS. LncRNA SRA expression was significantly higher in the women with PCOS than that in the controls. There was a significant positive correlation between lncRNA SRA expression and BMI in PCOS group. Furthermore, obesity positively associates with the high expression of lncRNA SRA in PCOS women but without the association in control women. In conclusion, we found that the lncRNA SRA expression is potentially associated with PCOS and it has positive correlation with obesity in PCOS, thereby suggesting that elevated lncRNA SRA might be an important mediator in adiposity-related processes in PCOS for susceptible individuals.
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