Spatial regression analysis is a statistical method used to perform modeling by considering spatial effects. Spatial models generally use a parametric approach by assuming a linear relationship between explanatory and response variables. The nonparametric regression method is better suited for data with a nonlinear connection because it does not need linear assumptions. One of the nonparametric regression methods is penalized spline regression (P-Spline). The P-spline has a simple mathematical relationship with mixed linear model. The use of a mixed linear model allows the P-Spline to be combined with other statistical models. PS-SAR is a combination of the P-Spline and the SAR spatial model so that it can analyze spatial data with a semiparametric approach. Based on data from monitoring the development of the HIV situation in 2018, the number of HIV cases in Indonesia shows a clustered pattern that indicate spatial dependence. In addition, the relationship between the number of positive cases and the factors tends to be nonlinear. Therefore, this study aims to apply the PS-SAR model to HIV case data in Indonesia. The resulting model is evaluated based on the estimates of autoregressive spatial coefficient, MSE, MAPE, and Pseudo R2. Based on the results, the PS-SAR model has an autoregressive spatial coefficient similar to the SAR model and has smaller MSE and MAPE than the SAR model.
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