Artificial intelligence (AI) has shown promise for diagnosing prostate cancer in biopsies. However, results have been limited to individual studies, lacking validation in multinational settings. Competitions have been shown to be accelerators for medical imaging innovations, but their impact is hindered by lack of reproducibility and independent validation. With this in mind, we organized the PANDA challenge—the largest histopathology competition to date, joined by 1,290 developers—to catalyze development of reproducible AI algorithms for Gleason grading using 10,616 digitized prostate biopsies. We validated that a diverse set of submitted algorithms reached pathologist-level performance on independent cross-continental cohorts, fully blinded to the algorithm developers. On United States and European external validation sets, the algorithms achieved agreements of 0.862 (quadratically weighted κ, 95% confidence interval (CI), 0.840–0.884) and 0.868 (95% CI, 0.835–0.900) with expert uropathologists. Successful generalization across different patient populations, laboratories and reference standards, achieved by a variety of algorithmic approaches, warrants evaluating AI-based Gleason grading in prospective clinical trials.
Dance challenges are going viral in video communities like TikTok nowadays. Once a challenge becomes popular, thousands of short-form videos will be uploaded within a couple of days. Therefore, virality prediction from dance challenges is of great commercial value and has a wide range of applications, such as smart recommendation and popularity promotion. In this article, a novel multi-modal framework that integrates skeletal, holistic appearance, facial and scenic cues is proposed for comprehensive dance virality prediction. To model body movements, we propose a pyramidal skeleton graph convolutional network (PSGCN) that hierarchically refines spatio-temporal skeleton graphs. Meanwhile, we introduce a relational temporal convolutional network (RTCN) to exploit appearance dynamics with non-local temporal relations. An attentive fusion approach is finally proposed to adaptively aggregate predictions from different modalities. To validate our method, we introduce a large-scale viral dance video (VDV) dataset, which contains over 4,000 dance clips of eight viral dance challenges. Extensive experiments on the VDV dataset well demonstrate the effectiveness of our approach. Furthermore, we show that short video applications such as multi-dimensional recommendation and action feedback can be derived from our model.
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