Background: Endometriosis and infertility are caused by reactive oxygen species or free radicals, which promote endometrial cell growth and adhesion in the peritoneal cavity. Genistein has been proven to protect cells against reactive oxygen species by scavenging free radicals and decreasing the expression of genes-associated stress responses.
Objective: This study was conducted to determine whether genistein also acts as an antioxidant by elevating superoxide dismutase (SOD) and glutathione peroxidase (GPx) in the peritoneal fluid of the endometriosis mice model.
Materials and Methods: This experimental study involved 32 healthy female mice (Mus musculus), aged between 2-3 months and weighing 20-30 gr. They were divided into negative control group (healthy mice without genistein), endometriosis group (endometriosis mice without genistein), treatment group that was given different doses of genistein, that is, 0.13; 0.26; 0.52; 0.78; 1.04; and 1.3 mg/day (n = 4/each). SOD level in the peritoneal fluid was measured using the quantitative colorimetric determination method, and a colorimetric assay measured the GPx levels.
Results: Results showed that the endometriosis model has lower SOD and GPx levels than the control group. The administration of genistein significantly normalized these changes. Genistein significantly increased SOD levels in the 0.13 mg and 0.26 mg treatment groups. Genistein also increased GPx levels significantly in all treatment groups.
Conclusion: Genistein increases SOD and GPx levels in the peritoneal fluid of an endometriosis mice model, and the change is dose-dependent.
Key words: Superoxide dismutase, Glutathione peroxidase, Endometriosis, Genistein.
Introduction: Stunting has been a global burden worldwide, resulting in severe outcomes, including inadequate brain development until mortality. Early breastfeeding initiation as a global strategy affects the success of continuous breastfeeding that influences the children’s growth and development. This study aimed to provide a literature review on how early breastfeeding initiation might help children avoid stunting.
Methods: We searched articles published from 2017 to 2022 in PubMed, Science Direct, Cochrane, and the Indonesia Database with keywords “Early breastfeeding initiation” OR “Early breastfeeding” OR” Early Initiation Breastfeeding” AND “stunting.” All data were gathered and analyzed.
Results: A total of 12 articles from 6690 articles met the inclusion, exclusion, and eligibility criteria. The mean of early breastfeeding initiation was 61,82%, with the lowest study in Chimborazo and Tungurahua, Ecuador, and stunting was 33,07% as the highest prevalence was in Chimborazo and Tungurahua, Ecuador, while the lowest in Saharawi refugee camps, Algeria. The mean prevalence of children who did not get early breastfeeding initiation and stunting occurred at 40,85%, and eight studies reported that early breastfeeding initiation was associated with stunting.
Conclusion: Early breastfeeding initiation can lower stunting risk in children. Early breastfeeding initiation ensures children obtain enough colostrum that enhances the children’s immunity and probability of exclusive breastfeeding, ensuring children obtain adequate nutritional intake and prevent stunting.
AIM: The coronavirus disease (COVID-19) pandemic has reportedly leaded to anxiety in women during pregnancy around the world. Anxiety during pregnancy is known to have negative outcomes for pregnancy and the baby. The aim of this study is to describe anxiety levels and behavioral changes of pregnant women during the COVID-19 pandemic at Fauziah Mother and Child Hospital Tulungagung, East Java.
METHODS: This descriptive study involved 30 pregnant women. The instrument used was a questionnaire asking about socio-demographic characteristics, gestational age, and the number of children, a questionnaire to assess attitudes and behavioral changes, and Generalized anxiety disorder-7-item Scale.
RESULTS: About 66.6% of pregnant women exhibited had mild anxiety levels, while 16.7% of them had moderate anxiety levels. Most pregnant women worried about their own, their children’s, unborn babies, and their elderly family members’ health, worked from home, avoided large-scale social activities and gatherings, and limited visits to health facilities.
CONCLUSION: The COVID-19 pandemic increases the likelihood of anxiety symptoms and changes in attitudes and behaviors in pregnant women.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.