BackgroundThis investigation is concentrated on how hematological and serum biochemical markers would change in streptozotocin-induced Insulin-Dependent diabetes mellitus(IDDM) in male adult wistar rats. Hematological parameters, serum protein electrophoresis parameters and hepatic transaminases level (SGOT-SGPT) were all measured in both control group rats (N=6) and diabetic group rats (N=6) and comparison between two groups was performed. Material and MethodSingle dose intraperitoneal injection of 60 mg/kg dose of streptozotocin(STZ) in male adult wistar rats, induces extensive necrosis in langerhans β-cell islets, because of its cytotoxicity. Experimental diabetes mellitus can be induced completely in less than 72 hours after STZ intraperitoneal injection. Streptozotocin(STZ) was purchased from Sigma company. Diabetic and control group rats were kept separately in different metabolic cages, and their blood glucose(BG), hematological parameters, serum protein electrophoretic pattern and hepatic transaminases level were analyzed and comparison was done. ResultsIn our investigation, Insulin-Dependent Diabetes Mellitus(IDDM) was completely induced one week after single intraperitoneal injection of 60 mg/kg BW. Diabetes mellitus induction was verified by measuring fasting plasma glucose level in blood samples of rats. Level of blood glucose, hematological parameters, serum protein electrophoretic pattern and hepatic transaminase enzymes level, were all measured. In diabetic group rats level of blood glucose (BG), hepatic transaminase enzymes (SGOT & SGPT), serum α1-globulin and β-globulin were significantly increased but in albumin, albumin/globulin ratio (A/G ratio) and serum α2-globulin a significant decrease was observed in diabetic rats in comparison with normal rats. ConclusionExtensive inflammation and tissue necrosis induced following diabetes mellitus induction in rats. Significant alterations were observed in serum protein electrophoresis fractions and hepatic transaminase enzymes level due to streptozotocin cytotoxic impacts on some tissues specifically liver.Because of extensive β-cells necrosis and degeneration caused by streptozotocin exposure, high level of blood glucose(diabetic hyperglycemia) was observed in diabetic rats. This type of experimentally induced diabetes mellitus would highly affect hematological parameters. Insulin-Dependent Diabetes Mellitus induced by streptozotocin, can lead to anemia, neutrophilia and lymphocytosis and also has decreasing effects on red blood cell indices (HGB, MCV, MCH, MCHC) in diabetic group rats.

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The worthwhile intellectual synthesis proposing that nothing makes sense except in light of context has also revolutionized pharmaceutical science putting patients’ genomic context at the center of attention in a rapidly developing area known as pharmacogenomics. As a result, an alternative approach to medicine referred to as personalized medicine was born considering the individual-specific genomic context the hardcore of any diagnostic, prognostic, and therapeutic intervention. Therefore, a considerable need has been created to address questions based on the underlying genotypic characteristics of patients. Depressive spectrum disorders are a cluster of closely-linked psychiatric disorders with a growing incidence rate across the world. Although there are multiple therapeutic approaches to treating depressive spectrum disorders, pharmacotherapy is still considered one of the most effective strategies. Among the therapeutic antidepressant drugs, selective serotonin reuptake inhibitors (SSRIs) are most widely prescribed. Fluoxetine (FLX) is a highly valued SSRI which is broadly ordered by psychiatric practitioners to treat miscellaneous psychological disorders, including depressive spectrum disorders, anxiety spectrum disorders, and obsessive-compulsive disorder. Although FLX therapy can bring about a positive therapeutic effect on a considerable proportion of depressed patients, it does not elicit a favorable response in 30-40% of patients owing to the presence of genomic variations negatively affecting the pharmacokinetic and pharmacodynamic characteristics of this medication. This challenging fact has led us to conduct current research on how genotypic variations at the inter-individual level can heavily affect the response to FLX therapy.                  Peer Review History: Received: 2 May 2022; Revised: 9 June; Accepted: 28 June, Available online: 15 July 2022 Academic Editor: Dr. Amany Mohamed Alboghdadly, Princess Nourah bint abdulrahman university, Riyadh, amalbgadley@pnu.edu.sa UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                                Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com Similar Articles:   PREVALENCE AND SEVERITY OF DEPRESSION AMONG PEOPLE LIVING WITH HUMAN IMMUNODEFICIENCY VIRUS IN YENAGOA, SOUTHERN NIGERIA