The article is devoted to one of the most important effects of local strains of lactic acid bacteria - the detection of anti-inflammatory action. For this purpose, studies were conducted on an experimental model of ulcerative colitis caused in experimental animals (mice). The data proving that the effect of various probiotic bacteria is unequal are presented. The ability of probiotic lactic acid bacteria in vitro and in vivo systems to influence the production of pro - and anti-inflammatory cytokines, to stimulate antimicrobial, anti-inflammatory, and protective effects have been shown. It is shown that it is necessary to study the specific effect of local lactobacillus strains on anti-inflammatory properties for a more adequate, effective selection of probiotic drugs in the treatment of intestinal ulcers. Data have been presented proving the positive effects of probiotic bacteria on the wound key.
In this work presents the results of studies on the ability to synthesize exopolysaccharides (EPS) by a local strain of Lactobacillus casei CO1, isolated from the epiphytic microflora of lilac flowers. In the IR spectrum of EPS, intense absorption bands were found, generally characteristic of the carbohydrate class. The monosaccharide composition was established and the molecular weight of the exopolysaccharide was determined. Revealed % RSA of EPS in the system of DPPH (diphenylpycrylhydrazil).
An exopolysaccharide (EPS) in the amount of 250 mg/l was obtained from the culture supernatant of Lactobacillus plantarum EB-2 grown in MRS broth. In the IR spectrum of EPS, intense absorption bands were found, generally characteristic of a class of carbohydrates. The molecular weight of the EPS obtained from L.plantarum EB-2 was 3.16x10 4 Da, the polydispersity index was 1.9. The EPS from L.plantarum EB-2 consisted from a mannose, glucose, galactose and rhamnose in an molare ratio of 21.7:12.4:2:1, respectively. An in vitro study of the antioxidant activity of L.plantarum EB-2 EPS in the diphenylpicrylhydrazil (DPPH) system showed that radical scavenging activity (RSA) has being increased depending on the concentration of the investigated EPS. The maximum RSA was detected at 4 mg/ml being 42%, which is more than the activity of ascorbic acid.
Research has been carried out to study the influence of "ProBioKorm Uz", a biologically active feed additive, on the development and physiological characteristics of rabbits of ‘New Zealand’ breed. During the experiment, 2 experimental and a control groups were formed. Adding "ProBioKorm Uz" to the main feed at the rate of 1% and 2% had an increase in experimental group rabbits’ live weight. Average live weight of them was higher by 5,7 %-3.8% than in the control group. Feed units composed 1.59%, dry matter 0.56 kg (3.61%) and crude protein 0.11 kg (3.59%) compared with the control group. Rabbits of experimental groups had higher indicators of erythrocytes concentration by 0.34-1.00 1012/l (10.34-19.53%), leukocytes - by 0.370-0.46 109/l (5.66-8, 06%), as well as a high level of hemoglobin by 7.42-11.08 g/l (6.81-10.08%) and total protein - by 2.40-4.48 (3.64-6, 42%).
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