Adult mice were submitted to different degrees o f protein restriction fo r five weeks (4.75, 9 .5,14.25 and 19% o Clinical and epidemiological observations suggest th at m aln u tritio n , m ainly protein deprivation, plays an im portant role in the development of infections which include protozoal d iseases2 8. A lthough m ost rep o rts show enhancement of infections in malnourished patients or experimental animals, some observations have shown increased resistance to malaria infection in rats that were submitted to protein restriction3 10. Moreover, while protein deprived mice infected with Leishmania mexicana showed arrest of lesion growth during the five initial weeks of infection, with subsequent development of non-healing lesions, normally nourished mice developed progressively healing lesions9.The effects of malnutrition on the evolution of Chagas' disease has not yet been evaluated. There are few reports showing enhancement of parasitemia and more severe lesions in the heart of infected rats submitted to diets with deficient amounts of thiamine, riboflavine, pantothenate or pyridoxine16 17 1819.
Cryptococcocal meningoencephalitis is always considered secondary to initial lung infection. Because of the unquestionable evidence of haematogenious spread from the lungs, few publications have reported about other possible primary sites of infection or other routes to the central nervous system. This study was designed to investigate the infiltrative pattern of C. neoformans in immunocompromised mice by treatment with dexamethasone. The infection was performed by nasal instillation (30 mice) or injection into the retro-orbital space (12 mice). From the group infected intranasally, 3 mice presented diffuse invasive fungal colonisation of the mucosa and submucosa. The histologic findings showed infiltrative growth along the periosteum, sometimes surrounded nervous endings of submucosa, invasion along the olfactory nerve and simultaneous meningeal involvement in 2 mice on the 6th and 8th day of infection. All mice infected into the retro-ocular space developed lesions containing numerous cryptococci in the local of the inoculum. Out of the main lesion we observed preferential growth along the perineural spaces with adherence to the perineurium, perivascular spaces and sometimes along aponeurosis. Simultaneous invasion of trigeminal ganglio and trigeminal branches was observed in 4 mice. These morphologic patterns suggest the hypothesis of direct infiltrative invasion of the central nervous system.
O artigo tem como tema o esgotamento psíquico decorrente do trabalho de agentes comunitários de saúde, e para nortear as análises, definiu-se como problema o levantamento das relações que se pode estabelecer entre o trabalho desenvolvido por agentes de saúde e o esgotamento psíquico. A partir daí objetivou-se contextualizar o tema esgotamento psíquico no âmbito dos estudos da psicopatologia; refletir sobre as condições de trabalho e seus estressores e analisar a atuação dos agentes de saúde. A escolha do tema foi motivada pelo exercício profissional de uma das autoras, que trabalha em uma Unidade Básica de Saúde no município de Areal/RJ e convive com agentes comunitários de saúde onde pode perceber as tarefas desenvolvidas, as ansiedades, as realizações e as dificuldades dos agentes no ambiente de trabalho. O texto fundamenta-se nos estudos da Psicologia Organizacional, da Psicopatologia para consolidar o tema esgotamento psíquico e textos disponibilizados pelo SUS sobre o agente de saúde. Metodologicamente, trata-se de uma pesquisa teórica, de base bibliográfica com consultas a artigos científicos, bem como, capítulos de livros sobre o tema. Considerou-se como resultado, que o esgotamento psíquico dos agentes comunitários de saúde, decorrente do trabalho que executam relacionam-se, em boa parte, com as condições de trabalho que envolvem: a exaustão emocional, fruto das relações interpessoais que vivenciam; a falta de equipamentos adequados no ambiente de trabalho; o cansaço gerado pelas visitas domiciliares a lugares distantes de difícil acesso, dentre outros.
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