BackgroundMultiple sclerosis (MS) is a central nervous system disease associated with irreversible progression of disability, which imposes a substantial socioeconomic onus. The objective of this study was to determine the economic impact of multiple sclerosis from the Brazilian household and healthcare system perspectives. Secondary objectives were to assess the impact of fatigue on daily living and health-related quality of life (HRQL) of MS patients.MethodsThis is a cross-sectional study in which Brazilian eligible patients attending eight major MS specialized sites answered an interview capturing data on demographics, disease characteristics and severity, comorbidities, resource utilization, fatigue, utilities and health-related quality of life from November/2011 to May/2012 . Costs were assessed considering a prevalence-based approach within 1 year of resource consumption and were estimated by multiplying the amount used by the corresponding unit cost. Patients were classified as having mild, moderate or severe disability according to the Expanded Disability Status Scale (EDSS).ResultsIn total, 210 patients who met eligibility criteria were included, 40 % had mild, 43 % moderate and 16 % severe disability; disability level was missing for 1 %. The average total direct cost per year was USD 19,012.32 (SD = 10,465.96), and no statistically significant differences were not observed according to MS disability level (p = 0.398). The use of disease modifying therapies (DMTs) corresponded to the majority of direct expenditures, especially among those patients with lower levels of disability, representing around 90 % of total costs for mild and moderate MS patients. It was also observed that expenses with medical (except DMTs) and non-medical resources are higher among patients with more severe disease. Worsening disability also had an important influence on health-related quality of life and self-perceived impact of fatigue on daily living.ConclusionOur data demonstrates the significant economic impact of MS on both Brazilian household and health system, in terms of DMTs and other disease management costs. When patients move upwards on the disease severity scale, costs with health resources other than drugs are significantly increased.
Hospitalizations and medications seem to be the most important resources funded by the Brazilian public health system and by patients and their families. Although further studies are necessary, as information on cost of this disease is scarce in Brazil, these findings suggest that there is a potential room for improving severe asthma care among Brazilian patients.
Results indicate that omalizumab as an add-on therapy is more cost-effective than standard-of-care therapy alone for Brazilian patients with uncontrolled severe allergic asthma, based on the World Health Organization's cost-effectiveness threshold of up to 3-times the gross domestic product.
BackgroundMultiple sclerosis (MS) is a chronic disease associated with several impacts; especially regarding patients’ health-related quality of life (HRQL). EuroQol 5 Dimensions questionnaire (EQ-5D) provides self-reported analysis of HRQL and utility scores. Although the British algorithm to convert EQ-5D responses into utility is the most used in the literature, national settings is more appropriate for health policy decision makers. A Brazilian algorithm is available, but not used in MS patients yet. Primarily, this study aimed to address potential differences in utility scores obtained through Brazilian and British value sets. Secondary objective was to determine the role of disability, fatigue and patients socio-demographic and clinical characteristics relevant to MS on the utility scores reported by Brazilian patients.MethodsCross-sectional study with MS patients treated in 8 Brazilian sites. Patients were interviewed about socio-demographic and clinical characteristics, self-reported disability level, HRQL and impact of fatigue on daily living. Disability level, HRQL and impact of fatigue were assessed using the Expanded Disability Status Scale (EDSS) and the Brazilian versions of EQ-5D-3L and Modified Fatigue Impact Scale (MFIS-BR), respectively. Patients were classified in subgroups according to EDSS (mild: 0–3; moderate: 4–6.5; severe: >7) and the self-perceived impact of fatigue (absent: ≤38 points; low: 39–58; high: ≥59). EQ-5D-3 L data was converted into a utility index using an algorithm developed by a Brazilian research group (QALY Brazil) and also the UK algorithm. Differences between utility scores were analysed through Wilcoxon test.ResultsTwo hundred and ten patients were included in the study. Utility index mean scores of 0.59 (SD = 0.22) and 0.56 (SD = 0.32) for the Brazilian and UK algorithms were observed, respectively, without statistically significant difference for the distribution of data (p = 0.586). However, when utility scores were lower than 0.5, Brazilian algorithm provided higher estimates than UK with a better agreement between the scores found closer to 1. The same trend was observed when data was stratified for EDSS and impact of fatigue, with statistically significant difference between scores in categories of mild/severe disabilities and absent/high impact of fatigue.ConclusionsResults suggest that Brazilian value set provided higher utility scores than the UK, particularly for measures below 0.5.
que colaboraram com suas experiências em pesquisa e conhecimentos específicos na área de síndrome metabólica. A todos da equipe da Unidade Clínica de Aterosclerose do Instituto do Coração da FMUSP que sempre muito bem me acolheram. Ao Dr. Rubens Kon, Diretor Técnico do Centro Saúde-Escola Samuel Barnsley Pessoa, onde a pesquisa foi realizada, e a toda a sua equipe pela recepção amigável e pelo apoio profissional que tornou possível a seleção de pacientes e realização das entrevistas. Agradeço a Janaína Steluti e ao Nilton Lopes da Silva, que colaboraram para a coleta de dados e, a Creuza Dal Bó por suas contribuições nas análises estatísticas.Aos membros da banca de avaliação para passagem de mestrado para doutorado direto e da banca de qualificação:A todos os funcionários da Faculdade de Ciências Farmacêuticas da USP pela indispensável colaboração na concretização deste trabalho.Aos amigos e colegas de profissão e de trabalho pelo incentivo e confiança.Meu agradecimento especial a todos os pacientes que deixaram suas atividades e compromissos pessoais para participar desta pesquisa.Ao meu pai (in memoriam) e aos meus irmãos pelo incentivo e carinho. A minha mãe, companheira incansável, pela presença, dedicação, amor e preces.Ao Luiz, Clara e Sophia, por tudo e sempre, meus carinhosos agradecimentos. Palavras-chave: Adesão ao tratamento. Aderência ao tratamento. Síndrome metabólica. Uso de medicamentos. 6 ABSTRACT SILVA, N.L. Metabolic syndrome patient compliance with treatment: access to and use of medicines and knowledge of cardiovascular risk factors. 2010. 125f. Tese (Doutorado) -Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, 2010.In a study including metabolic syndrome patients being treated in a Health-Medical School Center under the Public Brazilian Healthcare System (SUS), patient compliance with non-drug and drug treatment was evaluated as well as association/correlation between access to and use of medicines and the level of knowledge of cardiovascular risk factors. This study was approved by the Research Ethics Committee of the College of Pharmaceutical Sciences -University of São Paulo (USP) -on October 30 th, 2006 (Protocol Number 395) and it was performed in two parts: the first one was a cross-sectional study with the objective of evaluating patient compliance with drug treatment and determining association/correlation between analyzed variables; the second one was a prospective study, with a 12month follow-up and evaluations performed every three months, aimed at evaluating patient compliance with drug and non-drug treatment. The Measure Treatment Adherence (MTA), a variation of the Morisky-Green Test was used to assess patient behavior associated with the use of medicines. Parameters to evaluate compliance with a non-drug treatment were: to achieve a 10% weight reduction in total body weight and to perform a minimum of 30 minutes of activity at least three-times a week. Among 243 identified patients, 75 (30.9%) were included in this study. An average compliance score w...
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