Ethyl-3-oxo-2-(2-(4-sulfamoylphenyl)hydrazono) butanoate (2) on condensation with 6-methyl-2-oxo-4subsituted phenyl-1,2,3,4-tetrahydro pyrimidine-5-carbohydrazide (3a-e) to gave 4-(2-(3-methyl-1-(6-methyl-2-oxo-4subsituted phenyl-1,2,3,4-tetrahydro pyrimidine -5-carbonyl)-5-oxo-1H-pyrazol-4(5H)-ylidene) hydrazine) benzene sulfonamide (4a-e), which on reaction with benzaldehyde gives 4-(2-(1-(4-([1,1'-biphenyl]-4-yl)-3-(hydroxyl (phenyl) aryl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl) benzenesulfonamide(5a-e).The structures of all these compounds (4a-e) were recognized by analytical and spectral studies. The synthesized compounds were evaluated for their antimicrobial activity against various bacteria and fungi.
4-(2-(1-(4-aryl-3-(furan-2-yl(hydroxy)methyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl)-3-methyl5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-N-(thiazol-2-yl) benzene sulphonamides (2a-e) were synthesised by condensation of 4-(2-(1-(4-aryl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl)-3-methyl-5-oxo-1Hpyrazol-4(5H)-ylidene) hydrazinyl)-N-(thiazol-2-yl) benzene sulphonamide (1a-e) with furfuraldehyde. The structures of all the compounds (2a-e) were characterized duly. The compounds were also monitored for antimicrobial activity.
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