Singular spectrum analysis (SSA) is a method of time series analysis and is used in various fields, including medicine. A tremorogram is a biological signal that allows evaluation of a person’s neuromotor reactions in order to infer the state of the motor parts of the central nervous system (CNS). A tremorogram has a complex structure, and its analysis requires the use of advanced methods of signal processing and intelligent analysis. The paper’s novelty lies in the application of the SSA method to extract diagnostically significant features from tremorograms with subsequent evaluation of the state of the motor parts of the CNS. The article presents the application of a method of singular spectrum decomposition, comparison of known variants of classification, and grouping of principal components for determining the components of the tremorogram corresponding to the trend, periodic components, and noise. After analyzing the results of the SSA of tremorograms, we proposed a new algorithm of grouping based on the analysis of singular values of the trajectory matrix. An example of applying the SSA method to the analysis of tremorograms is shown. Comparison of known clustering methods and the proposed algorithm showed that there is a reasonable correspondence between the proposed algorithm and the traditional methods of classification and pairing in the set of periodic components.
The human central nervous system is the integrative basis for the functioning of the organism. The basis of such integration is provided by the fact that the same neurons are involved in various sets of sensory, cognitive, and motor functions. Therefore, the analysis of one set of integrative system components makes it possible to draw conclusions about the state and efficiency of the other components. Thus, to evaluate a person’s cognitive properties, we can assess their involuntary motor acts, i.e., a person’s subsensory reactions. To measure the parameters of involuntary motor acts, we have developed a strain gauge measuring system. This system provides measurement and estimation of the parameters of involuntary movements against the background of voluntary isometric efforts. The article presents the architecture of the system and shows the organization of the primary signal processing in analog form, in particular the separation of the signal taken from the strain-gauge sensor into frequency and smoothly varying components by averaging and subtracting the analog signals. This transfer to analog form simplifies the implementation of the digital part of the measuring system and allowed for minimizing the response time of the system while displaying the isometric forces in the visual feedback channel. The article describes the realization of the system elements and shows the results of its experimental research.
BackgroundThe objective of the study was to develop a system for the precision diagnostics of pathologies of motor brain regions based on tensometric measurement and to explore its diagnostic capabilities.Materials and methodsTremor is a syndrome that indicates the abnormal state of the central nervous system, primarily in the motor brain regions. Analysis of tremor parameters provides significant information about the changes in the body motion control and can be used as an objective index of the central nervous system state. Existing methods are aimed at the analysis of visible tremor based on the use of different sensors. We suggest an alternative approach based on the use of a tensometric system performing tremor measurements when the tremor appears on the background of voluntary isometric efforts. The key advantage of our approach is that it allows to determine the tremor before its visible manifestation. In the article, we describe hardware implementation of our tremor analysis system.ResultsIn the article, we represent the new methodology and the original equipment based on the control of isometric effort. Isometric effort formed by a patient is controlled with the use of a feedback system on the patient’s monitor. We evaluated the performance of our equipment with more than 400 healthy volunteers and patients with various pathologies of the central nervous system motor regions, and the results of the investigations, allowing to identify tremor parameters typical for parkinsonism, are represented in our article.ConclusionTesting of the system confirmed its high diagnostic validity and reliability, high sensitivity, simplicity and high speed of information processing. The approach based on tensometric measurements is very promising for the diagnostics of Parkinson disease and dysfunctions of a central nervous system.
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