and on the information campaign This study has been approved by all Ethical Commettees of the centers. Results:The first survey was conducted between March 16th and April 30th. 1027 questionnaires were collected. Mean age was 64 yrs (SD 11.7), 58% were women, 49% had low educational level. 80% and 20% received i.v. and oral treatment, respectively. As for pts feelings, 45.5% indicated that their fears related to cancer increased because hope in recovery diminished (23%). Courage of coping with tumor was increased in 26%, unchanged in 64%; 95% perceived a high availability of healthcare facilities and 97.6% declared confidence in the treating teams, while 65.3% stated that the information received from the Government and local bodies was confusing.Conclusions: Although half of the pts had more fears and concerns about the epidemic, they feel reassured, maintain trust in healthcare facilities and a good communication with doctors and nurses. Due to the epidemic course, the second survey could not yet be performed and data will be available by June.

Breast cancer is the second most common malignant tumor worldwide and the most common oncological disease among women. This article presents our experience in postoperative Radiotherapy (RT) in 341 patients with Early Breast Cancer (EBC) after Breast-Preserving Surgery (BPS). Emphasis is placed on the indications and Clinical Target Volumes (CTV) for radiotherapy. The significant effect of postoperative RT in terms of Local Tumor Control (LTC), long-term recurrence-free survival and overall survival is reported. The main goal of this article is to establish high-tech radiotherapy after BPS in early BC as the main local method, optimizing the treatment and cosmetic results.

Uterine carcinosarcoma (UCS) is a rare aggressive neoplasm.We present a clinical case with UCS, developed during along-term five years adjuvant tamoxifen treatment and ovarian suppression with LHRH agonist on the occasion of invasive ductal breast carcinoma. Crucial for obtaining diagnosis of this rare aggressive neoplasm is the strict pathohistological and immunohistochemical analysis, carried out by an experienced pathologist. Every patient with a history of breast carcinoma is a subject for periodic monitoring. Genital bleeding is required to perform a separated endometrial abrasion with a precise histological study. For UCS / III C2 FIGO stage without distant metastases is necessary to conduct a maximal surgical tumor reduction, involving ever total abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic and para-aortic lymphadenectomy, peritoneal cytology, and omentectomy, followed by a combined simultaneous chemo-radiotherapy of tumor bed and pelvic lymph nodes, definitive radiotherapy of para-aortical lymph nodes, as well as adjuvant chemotherapy.

The pulmonary sarcomatoid carcinoma (PSC) is extremely rarely lung neoplasm. A woman at the age of 55 with a local advanced pulmonary sarcomatoid carcinoma of the right lung and CT data on bilateral adrenal metastases and three brain metastases were established. Diagnosis is placed after bronchoscopy with biopsy and detailed pathochistological and immunohistochemical analysis. PSC is extremely malignant and with high risk of distant haematogenic metastases. This rare clinical case support the need for strict pathohistological and immunohistochemical analysis, a difficult pathohistological differential diagnosis with other primary malignant lung tumors and the assessment of complex treatment. In order to improve the healing results and survival of patients, timely diagnosis is required at early stage with surgical treatment and subsequent adjuvant chemotherapy and targetеd therapy after genetic analysis of surgery or biopsy tissue material.

The gastrointestinal metastases (GIM) of breast carcinoma (BC) are a rare clinical finding, even more rarely diagnosed as initial symptoms at unknown BC. We present a 50-year-old woman with metastases in the terminal ileum combined with multiple bone metastases from an unknown invasive carcinoma of left mammary gland. Gastrointestinal metastases are rarely observed in invasive lobular breast carcinoma. Differential diagnosis between intestinal metastases from primary BC and primary intestinal neoplasm is extremely difficult. Determination of tumor pathohistogenesis require careful pathohistological and immunohistochemical analysis. Complex treatment follows the primary neoplasm principles. The prognosis in such clinical cases is unfavorable, but after timely complex oncological treatment, including emergency operation, chemotherapy, hormone and target therapy, 36 monthly survival is achieved. Keywords: gastrointestinal metastases; invasive lobular breast carcinoma; pathohistological analysis; immunohistochemical analysis; complex treatment.

Colonic MALT lymphoma is a rare disease. Due to rare diagnosis, randomized studies are missing to determine the optimal therapeutic approach. We present a 77-year-old patient with Mucosa-Associated Lymphoid Tissue (MALT) lymphoma of the colon, which is diagnosed after colonoscopy with biopsy and precise pathohistological and immunohistochemical analysis. Treatment includes surgery /hemicolonectomy, followed by 6 cycles of chemotherapy- R-COPP regimen. Two years after diagnosis, the patient is in good condition with normal quality of life without recurrence and distant spread of the disease. Through this article, our goal is to support medical literature with another clinical case that demonstrate the need for thorough and precise diagnosis by immunohistichemic analysis and an assessment of optimal complex treatment. Keywords: MALT lymphoma; non-Hodgkin's lymphoma; pathohistological analysis; immunohistochemical analysis; chemotherapy; Complex treatment.

operation, including extirpation of the rectum a modo Miles with simultaneous partial resection of the stomach was performed.From the examinations: Rectocolonoscopy: Approx. 4 cm from the anorectal line, a tumor process on the posterior wall, ulcerated and easily bleeding to the touch was found. A biopsy for histological verification was taken.CT of the thorax and abdomen: Lung, mediastinum, liver, gallbladder, pancreas, spleen, adrenal glands, kidneys -without pathology observations; There are no pathologically enlarged paraaortic, pelvic and inguinal lymph nodes. Small pelvis:Rectum -Near the sphincter along the lateromedial contour on the left, there is a reinforcing intraluminal formation. Free perirectal adipose tissue, no visible changes.Stomach-In the middle third, along the greater curvature, there is an intramural lesion measuring 35/24 mm, with calcification on

Chordoma is a rare malignant neoplasm. It is usually diagnosed at an advanced stage, which contributes for the poor prognosis and high mortality. In this article, we will consider three clinical cases with locally advanced chordomas in order to emphasize the importance of early diagnosis by MRI and the need for strict pathohistological and immunohistochemical analysis. Our observations reported late diagnosis, slow tumor growth, and numerous partial tumor resections, enhancing the mitotic activity of chordoma tumor cells. After numerous operations, rapid local tumor progression with aggressive infiltration of adjacent healthy tissues was observed. Hematogenous dissemination is observed after the third year of primary diagnosis and repeated surgical interventions of locally advanced chordoma. The prognosis in locally advanced chordomas is extremely unfavorable. Early diagnosis requires MRI and biopsy with exact pathomorphological and immunohistochemical analysis. To improve the treatment results, early diagnosis and complex treatment, including radical surgery and assessment of the need for high-tech postoperative radiotherapy are required.