Prior work by Radin et al. (2012 , 2016) reported the astonishing claim that an anomalous effect on double-slit (DS) light-interference intensity had been measured as a function of quantum-based observer consciousness. Given the radical implications, could there exist an alternative explanation, other than an anomalous consciousness effect, such as artifacts including systematic methodological error (SME)? To address this question, a conceptual replication study involving 10,000 test trials was commissioned to be performed blindly by the same investigator who had reported the original results. The commissioned study performed confirmatory and strictly predictive tests with the advanced meta-experimental protocol (AMP), including with systematic negative controls and the concept of the sham-experiment, i.e., counterfactual meta-experimentation. Whereas the replication study was unable to confirm the original results, the AMP was able to identify an unacceptably low true-negative detection rate with the sham-experiment in the absence of test subjects. The false-positive detection rate reached 50%, whereby the false-positive effect, which would be indistinguishable from the predicted true-positive effect, was significant at p = 0.021 ( σ = −2.02; N = 1,250 test trials). The false-positive effect size was about 0.01%, which is within an-order-of-magnitude of the claimed consciousness effect (0.001%; Radin et al., 2016 ). The false-positive effect, which indicates the presence of significant SME in the Radin DS-experiment, suggests that skepticism should replace optimism concerning the radical claim that an anomalous quantum consciousness effect has been observed in a controlled laboratory setting.

Science is always presupposing some basic concepts that are held to be useful. These absolute presuppositions (Collingwood) are rarely debated and form the framework for what has been termed ''paradigm'' by Kuhn. Our currently accepted scientific model is predicated on a set of presuppositions that have difficulty accommodating holistic structures and relationships and are not geared towards incorporating non-local correlations. Since the theoretical models we hold also determine what we perceive and take as scientifically viable, it is important to look for an alternative model that can deal with holistic relationships. One approach is to generalise algebraic quantum theory, which is an inherently holistic framework, into a generic model. Relaxing some restrictions and definitions from quantum theory proper yields an axiomatic framework that can be applied to any type of system. Most importantly, it keeps the core of the quantum theoretical formalism. It is capable of handling complementary observables, i.e. descriptors which are non-commuting, incompatible and yet collectively required to fully describe certain situations. It also predicts a generalised form of non-local correlations that in quantum theory are known as entanglement. This generalised version is not quantum entanglement but an analogue form of holistic, non-local connectedness of elements within systems, predicted to occur whenever elements within systems are described by observables which are complementary to the description of the whole system. While a considerable body of circumstantial evidence supports the plausibility of the model, we are not yet in a position to use it for clear cut predictions that could be experimentally falsified. The series of papers offered in this special issue are the beginning of what we hope will become a rich scientific debate.

The current state of evidence does not allow conclusions to be drawn on whether supplementation of Zn is beneficial for the prevention or treatment of AD, although a subclinical deficiency appears common in the elderly and subjects with AD. Dietary studies with animals suggest that the impact of dietary Zn on cognitive performance depend on additional nutrients. Further studies are necessary to determine whether Zn deficiency is a risk factor for AD in general terms or under certain dietary circumstances only.

SummarySpirituality is a topic of recent interest. Mindfulness, for example, a concept derived from the Buddhist tradition, has captivated the imagination of clinicians who package it in convenient intervention programs for patients. Spirituality and religion have been researched with reference to potential health benefi ts. Spirituality can be conceptualised as the alignment of the individual with the whole, experientially, motivationally and in action. For spirituality to unfold its true potential it is necessary to align this new movement with the mainstream of science, and vice versa. Hence, both a historical review, and a systematic attempt at integration is called for, which we are trying to give here. It is useful to go back to one of the roots: parapsychology. Parapsychology was founded as a counter movement to the rising materialist paradigm in the 19th century. Adopting the methods of the natural sciences, it tried to prove the direct infl uence of consciousness on matter. After 125 years this mission must be declared unaccomplished. Surveying the database of parapsychological research it is obvious that it will not convince sceptics: Although there are enough exceptional fi ndings, it has in general not been possible to reproduce them in replication experiments. Th is is, however, a characteristic signature of a category of eff ects which we call eff ects of generalised entanglement, predicted by a theoretical model analogous to quantum theory. Using this perspective, parapsychological eff ects can be understood, and the original aim of the founding fathers can be recovered, as well as a new, systematic understanding of spirituality be gained. Generalised entanglement is a formal and scientifi c way of explaining spirituality as alignment of an individual with a whole, which, according to the model, inevitably leads to non-local correlations.

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