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Background Vaccination is an essential strategy for mitigating the COVID-19 pandemic. Besides its significance as a public health measure, vaccination is a sophisticated example of modern biotechnology. Since vaccination gives the human body an ability that it does not naturally possess, the question arises as to its classification as Human Enhancement. Main Body Exemplified on a selection of different definitions, we conclude that vaccinations may indeed be classified and treated as a form of Human Enhancement. This raises some ethical issues that are notorious in the broad field of Human Enhancement. A study with N = 67 participants revealed that vaccinations are perceived neither as a clear nor poor example of Human Enhancement. Conclusion  We argue that qualifying vaccination technology as Human Enhancement does not provide convincing arguments to reject vaccination. By examining the Human Enhancement debate and the similarities to the issue of vaccination shown here, policymakers can learn valuable lessons regarding mass vaccination programs’ current and future handling.

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Solutions to the Fermi paradox either deny the existence of extraterrestrials or offer alternative reasons to explain the non-occurrence of a first contact. While the latter, more optimistic approaches generally assume the existence of extraterrestrials, they simultaneously hint to limited future detectability. If solutions to the Fermi paradox are accepted as true, they must be evaluated in terms of how they affect the likelihood of success of future SETI efforts. Some solutions may lead to the so-called Fermi constraint: in order to explain why there has not been any contact so far, optimistic solutions to the Fermi paradox have to accept assumptions that, if the solution is assumed to be correct, indicate a very low probability of future contact. In other words: they are not here, and that is why they may never appear.