Our analysis indicated that ALK-EML4 positive NSCLC comprised a unique subgroup of adenocarcinomas with distinct clinicopathological characteristics. Incidence of ALK positivity was found to be higher in females and never smokers. These patients have distinct pathological and radiological characteristics. Crizotinib, whether used upfront or as subsequent therapy was found to be superior in PFS (not yet reached at the time of writing this article), and maintaining quality of life as compared to cytotoxic chemotherapy.
Back ground: In the recent years, the use of herbal products has been increasing in developing countries. Psidium guajava Linn. (Guava), family: Myrtaceae is an important dietary plant used traditionally for medicinal purpose around the world. Objectives: The main objective of this research is to investigate the phytochemicals present in leaves and screen the anthelmintic activity of Psidium guajava leaves against Indian adult earthworms Pheretima posthuma. Method: The phytochemical screening was done by following standard protocols. The Anthelmintic assay was carried as per the method followed by Ajaiyeoba EO et. al, with minor modifications. Three concentrations (25, 50 and 100 mg/ml) of extract were studied, which involved for the determination of time of paralysis and time of death of the test worms. Results: It was found that ethanol extract of Psidium guajava leaves exhibited significant anthelmintic activity at high conc. (100 mg/ml). Albendazole in same concentration as that of extract was used as standard reference and saline water as control. Conclusion: Findings of the present investigations confirms that, the ethno-medicinal claim of anthelmintic activity of this plant is genuine. Therefore, it can be used as a source of natural anthelmintic and used in drug formulations for treatment of diseases.
Background: Non Hodgkins lymphoma is the most prevalent hematopoietic neoplasm, representing approximately 4% of all cancer diagnoses and ranking seventh in frequency among all cancers. Most of the data that we have is of west and data pertaining to Indian subcontinent is lacking. The aim of this study was to study clinical profile, prognostication, and assess treatment outcome in DLBCL patients in a tertiary care hospital.Methods: 100 patients of DLBCL reporting to a tertiary care hospital between 2013 to 2016 were chosen for the study. All patients were subjected to routine investigation and specialized investigation including bone marrow examination and Positron emission tomography. Patients were treated with standard treatment protocol and their response to treatment were assessed.Results: Study revealed male predominance with median age of onset was 45.6. Anorexia was the most common symptom. Lymphadenopathy was the most common sign. Bone marrow involvement and anemia commensurate each other. Only16% cases presented in IPI score 4 and 5. Complete remission achieved with treatment in stage l and ll disease were beyond 90% and steep decline in complete remission with treatment was noted in stage lll and lV (~70%). 76% patients with DLBCL showed CR, 12.5% showed PR.Conclusions: The present study revealed male preponderance with relatively early age of onset compared to western population. B- cell lymphoma (DLBCL) constituted maximum number of NHL cases (89%). We have found a higher proportion of B cell subtype as compared to other Indian studies, at the same time it corroborated with the findings of western studies. Complete remission achieved with treatment in stage l and ll disease were beyond 90% and steep decline in complete remission with treatment was noted in stage lll and lV (~70%).
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