Background: hMPG initiates repair of mutagenic and tumorigenic modified purine bases. Results: Two germ line hMPG variants showed reduced activity due to low affinity for DNA and facilitated lesion-induced mutations. Conclusion: Changes in amino acid sequence alter the function of hMPG, leading to genomic instability. Significance: Individuals possessing these hMPG variants may be at higher risk for genomic instability-related diseases.
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