BACKGROUNDAndrogenetic alopecia (AGA) is a patterned hair loss occurring due to systemic androgen and genetic factors. It is the most common cause of hair loss in both genders. In recent years, many studies investigating the relation between systemic diseases and androgenetic alopecia presented controversial results.OBJECTIVESIn this study we aimed to investigate the frequency of androgenetic alopecia, the presence of accompanying systemic diseases, the relation between body mass index and androgenetic alopecia severity and the association of hyperandrogenemia signs with androgenetic alopecia in patients who referred to our outpatient clinic.METHODSPatients who referred to our clinic between October 2013 and May 2014 were included in the study. Diagnosis of androgenetic alopecia was made upon clinical findings. Presence of seborrhea and acne in both genders, and hirsutism in women, were examined. Age, gender, smoking habit and alcohol consumption, age of onset of androgenetic alopecia, family history, accompanying systemic diseases and abnormalities of menstrual cycle were recorded.RESULTS954 patients (535 women, 419 men) were included in the study. Androgenetic alopecia prevalence found was 67.1% in men and 23.9% in women. Androgenetic alopecia prevalence and severity were correlated with age in both genders (p=0,0001). Frequency of accompanying systemic diseases were not significantly different between patients with and without androgenetic alopecia (p=0,087), except for hypertension, which was significantly more frequent in men with androgenetic alopecia aged between 50 and 59 years. Study limitations: Despite the exclusion of other causes of alopecia, differentiation of Ludwig grade 1 AGA from telogen effluvium based on clinical features alone is difficult.CONCLUSIONSIn our study the rate of androgenetic alopecia was found to be higher than the other studies made in Asian and Caucasian populations.

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Fabry disease is an x-linked recessive metabolic storage disorder due to the deficiency of lysosomal α-galactosidase A, and the subsequent accumulation of glycosphingolipids, throughout the body. The presence of diffuse angiokeratomas in Fabry disease is a cutaneous hallmark but it is not a specific one. In this case report, we observed the features of a case of Fabry disease and reviewed the diagnostic approach to angiokeratomas.

Mastositozis başta deri olmak üzere, çeşitli dokularda mast hücrelerinin sayıca artışı ve mast hücre mediatörlerinin salınımı ile karakterli hem erişkinlerde hem de çocuklarda nadir görülen bir grup hastalıktır.Bu çalışmada soliter mastositom tanısı alan iki olgu sunulmaktadır. Her iki olgunun klinik ve histopatolojik bulgularına ek olarak, sistemik tutulum olmaksızın bir olguda büllöz soliter mastositom mevcuttur.Anahtar kelimeler: Kutanöz, mastositozis, patoloji ABSTRACT: Solitary cutaneous mastocytomaMastocytosis is a group of diseases characterised by emission of mast cell mediators and increase of mast cells primarily in skin and other tissues. It is a rare disease encountered both in adults and children. Two cases of solitary mastocytoma are presented in this study. In addition to the typical clinical and histopathological findings, one of the cases shows bullous solitary mastocytosis without systemic involvement.

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